NMN (nicotinamide mononucleotide) has become a popular ingredient in the biohacking and longevity space. As interest grows, so does the number of NMN supplements available — from simple, single-ingredient options to more complex formulations that combine NMN with additional nutrients.
With so many choices, the key question isn’t which NMN supplement is best — it’s:
This guide explains how NMN supplements differ, what matters when comparing formulations, and how to choose an option that supports everyday wellbeing without unnecessary complexity.
NMN is involved in the body’s natural NAD⁺ synthesis pathways. NAD⁺ is a coenzyme that plays a role in normal cellular energy metabolism and metabolic processes.
In practical terms, NAD⁺ is involved in:
NMN supplements are designed to support the body’s existing biochemical pathways rather than supplying NAD⁺ directly.
In Australia, if an NMN product is supplied as a listed medicine, it must meet Therapeutic Goods Administration (TGA) requirements for quality, safety, labelling and permitted indications. Consumers can check whether a product is included on the Australian Register of Therapeutic Goods (ARTG) by looking for an AUST L number on the label.
While NMN is the core ingredient, formulation determines how a supplement fits into real life.
Key factors to consider include:
The most effective supplement is the one you’ll take consistently — not the most complex formula on the shelf.
NMN 250
Lower-dose NMN formulations are often chosen by people who are new to NMN or who prefer a conservative, everyday approach.
This type of NMN supplement may suit those who:
NMN-only formulations are easy to integrate alongside other supplements and flexible across different routines.
NMN 500 (Higher Strength)
Higher-strength NMN supplements provide a greater amount of NMN per dose while maintaining a simple, single-ingredient format.
This option may appeal to individuals who:
Higher dose does not mean “better” — it simply reflects a different formulation choice.
NMN Blends: Combining NMN with Other Nutrients
Some NMN supplements combine NMN with additional ingredients commonly included in general wellness formulations. These blends are designed for convenience, allowing multiple nutrients to be taken together.
NMN with CoQ10, Alpha Lipoic Acid and Green Tea
Some formulations combine NMN with ingredients often included in cellular or metabolic support supplements.
These blends may suit people who prefer a single, all-in-one supplement rather than managing multiple products.
NMN with Activated B Vitamins
B vitamins are essential nutrients involved in:
Activated forms are commonly included in supplements for individuals who prefer pre-converted vitamin forms.
This type of NMN formulation may appeal to people who:
When choosing blended formulations, it’s important to consider total nutrient intake from all sources.
NMN with Glycine
Glycine is an amino acid involved in nervous system function and is often included in relaxation-focused routines.
NMN and glycine formulations may suit individuals who:
As with all supplements, personal response and routine are key factors.
Rather than comparing supplements solely by dose or ingredient count, consider how a product fits into everyday life.
Helpful questions include:
A supplement that integrates easily into your routine is more likely to be used consistently.
Understanding NMN Dosage
Higher NMN doses are not inherently better.
Different NMN doses reflect different formulation approaches and consumer preferences. If a product is supplied as a listed medicine in Australia, it must be formulated within permitted parameters and supported by evidence for its approved indications.
Choosing a dosage should be based on:
—not comparison or escalation.
What to Look for on an NMN Supplement Label
When choosing an NMN supplement, look for:
Clear labelling and transparency matter more than marketing language.
NMN as Part of a Broader Wellbeing Routine
NMN supplementation is best viewed as part of a broader approach to wellbeing that includes:
There is no one-size-fits-all NMN supplement — only options that align more closely with individual needs and lifestyles.
Final Thoughts
Choosing an NMN supplement doesn’t need to be complicated.
By understanding how NMN works, why formulations differ, and how supplements fit into everyday routines, it’s possible to make an informed choice with confidence.
The right NMN supplement isn’t the strongest or most complex — it’s the one that fits your lifestyle and supports consistency over time.
NMN (nicotinamide mononucleotide) has become a focal point in discussions around energy, performance and healthy ageing. As interest in cellular health continues to grow, NMN is increasingly studied for its role in supporting the body’s natural production of NAD⁺ — a molecule essential for normal cellular energy and metabolic processes.
With growing attention often comes confusion or overstatement. This article takes a measured, evidence-led look at what NMN is understood to support, how it works in the body, and how current research is shaping interest in this ingredient — without overstating outcomes or stepping beyond approved indications.
To understand NMN, it helps to start with NAD⁺ (nicotinamide adenine dinucleotide).
NAD⁺ is a molecule present in every living cell and is involved in many essential biological processes, including:
NAD⁺ plays a central role in mitochondrial function. Mitochondria are often described as the “energy generators” of the cell, converting nutrients into usable energy. Adequate NAD⁺ availability supports these processes functioning efficiently as part of normal cellular metabolism.
Research indicates that NAD⁺ levels naturally decline with age. This change is thought to be influenced by several factors, including:
As NAD⁺ availability decreases, the body may need to work harder to maintain normal cellular energy production and repair processes. This has led researchers to explore nutritional strategies that support the body’s existing NAD⁺ pathways rather than attempting to replace NAD⁺ directly.
NMN (nicotinamide mononucleotide) is a naturally occurring compound found in small amounts in certain foods.
Within the body, NMN functions as a direct precursor to NAD⁺. Rather than supplying NAD⁺ itself, NMN provides a compound that can be absorbed and converted into NAD⁺ inside cells.
This precursor role is why NMN has become an area of scientific interest in research focused on cellular energy production and metabolic health.
One of the primary research areas around NMN relates to energy production at the cellular level.
NAD⁺ is required for key enzymatic reactions that allow cells to convert carbohydrates, fats and proteins into energy. When NAD⁺ is available in sufficient amounts, these reactions can proceed normally, supporting:
By supporting NAD⁺ production, NMN helps maintain the body’s natural energy-producing pathways. This aligns with approved indications for listed medicines relating to energy production and nervous system support.
Because mitochondria rely on NAD⁺ to function efficiently, NMN is often discussed in the context of physical performance and endurance.
Importantly, NMN is not a stimulant. It does not force energy production or act like caffeine. Instead, it supports the underlying cellular processes that allow energy to be generated naturally as part of normal metabolism.
For individuals interested in sustainable energy support — rather than short-term stimulation — this distinction is key.
Oxidative stress is a normal biological process that occurs when free radicals are produced faster than the body can neutralise them. Over time, oxidative stress can contribute to cellular wear and tear.
Listed medicines containing NMN are permitted to carry indications related to helping reduce free radical damage to body cells. This reflects NMN’s role in supporting the body’s natural antioxidant defence systems, rather than acting as a direct antioxidant itself.
Antioxidant support is a foundational element of cellular health and is commonly discussed in the context of healthy ageing — not as a treatment or prevention of disease, but as part of maintaining normal cellular function over time.
NAD⁺ also plays a role in normal nervous system signalling. Nerve cells are highly energy-dependent, and efficient energy metabolism is important for:
By supporting NAD⁺ availability, NMN contributes to the normal functioning of the nervous system, consistent with approved general health indications.
Many metabolic processes rely on NAD⁺-dependent enzymes. These processes influence how the body utilises nutrients and maintains internal balance.
Supporting NAD⁺ production through NMN may help maintain normal metabolic function, which underpins overall wellbeing. This is one reason NMN is often included in formulations alongside other ingredients traditionally used to support metabolic or cardiovascular health, such as CoQ10 or alpha lipoic acid.
Much of the early research into NMN has been conducted in preclinical models, where NMN supplementation has been shown to increase NAD⁺ levels within cells.
Human research is continuing to develop, with emerging studies examining how oral NMN supplementation influences NAD⁺ levels and markers of cellular function. While these findings are of scientific interest, NMN is not a medicine for the treatment or prevention of disease, and research is ongoing.
A responsible, evidence-based perspective recognises:
The concept of longevity is often misunderstood. In a scientific and regulatory context, it does not mean extending lifespan or preventing disease.
Instead, healthy ageing refers to supporting normal cellular processes as the body ages. By supporting cellular energy production, antioxidant defences and nervous system function, NMN is positioned as part of a broader approach to maintaining vitality over time.
In Australia, listed medicines are regulated to ensure that claims are supported by evidence and do not overstate outcomes.
For NMN products included on the Australian Register of Therapeutic Goods (ARTG), permitted indications focus on:
This regulatory framework helps ensure consumers receive clear, accurate and trustworthy information.
NMN is neither a cure-all nor a miracle compound. It is a well-researched NAD⁺ precursor that supports fundamental cellular processes involved in energy metabolism and cellular maintenance.
As interest in preventative health and longevity continues to grow, NMN represents a science-led approach to supporting everyday vitality — grounded in regulation, transparency and ongoing research.
As interest in cellular health and longevity continues to grow, NAD⁺ (nicotinamide adenine dinucleotide) has become a molecule of significant scientific and public attention. Alongside this interest has emerged a range of products and therapies designed to support the body’s natural NAD⁺ levels.
The most commonly discussed options include NMN (nicotinamide mononucleotide), NR (nicotinamide riboside) and intravenous (IV) NAD⁺.
Although these options are often mentioned together, they differ meaningfully in how they interact with the body, how they are delivered, and how they are regulated. Understanding these differences helps consumers make informed decisions without confusion or overstatement.
This article provides a clear, science-led overview of NMN, NR and IV NAD⁺, focusing on how each supports NAD⁺ through different mechanisms.
NAD⁺ is a molecule found in every living cell. It plays an essential role in a wide range of biological processes, including:
· Cellular energy production
· Normal metabolic processes
· Supporting enzymes involved in cellular maintenance
· Nervous system signalling
NAD⁺ functions as a coenzyme in redox reactions, which allow cells to convert nutrients into usable energy. It is also involved in pathways related to cellular repair and resilience.
Research shows that NAD⁺ levels naturally decline with age. This has led to growing interest in nutritional and lifestyle approaches that support the body’s existing NAD⁺ synthesis pathways.
When exploring ways to support NAD⁺, it helps to distinguish between two broad strategies:
1. Providing NAD⁺ directly
2. Providing NAD⁺ precursors
NAD⁺ precursors are compounds the body can absorb and then convert into NAD⁺ inside cells. NMN and NR fall into this category.
IV NAD⁺, by contrast, involves delivering NAD⁺ directly into the bloodstream via intravenous infusion.
Each approach interacts with the body differently and comes with distinct practical and regulatory considerations.
NMN (nicotinamide mononucleotide) is a naturally occurring compound involved in the body’s primary NAD⁺ synthesis pathway.
How NMN Works in the Body
Once absorbed, NMN is converted into NAD⁺ through enzymatic processes that occur inside cells. Because NMN sits one step away from NAD⁺ in this pathway, it has become an area of interest in research focused on cellular energy and metabolic function.
NMN is found naturally in small amounts in foods such as broccoli, cabbage and avocado, although dietary intake provides relatively low quantities.
Oral NMN supplements are designed to support the body’s existing NAD⁺ production processes. Research indicates that NMN supplementation can increase NAD⁺ levels in cells, although research is ongoing and continues to develop.
In Australia, NMN supplements that are listed on the Australian Register of Therapeutic Goods (ARTG) must meet strict requirements for quality, safety, labelling and permitted indications.
NR (nicotinamide riboside) is another compound that contributes to NAD⁺ synthesis.
How NR Is Converted
Before NR can contribute to NAD⁺ production, it must first be converted into NMN within the body. After this conversion step, it enters the same biochemical pathway that leads to NAD⁺.
This additional step represents a key biochemical distinction between NR and NMN. Both ultimately support NAD⁺ production, but they do so via slightly different processes.
NR in Supplements
NR has been available in supplement form for several years. In Australia, NR supplements are also regulated when listed on the ARTG and must comply with permitted indications and labelling requirements.
IV NAD⁺ involves administering NAD⁺ directly into the bloodstream via intravenous infusion. This approach is typically delivered in a clinical or wellness clinic setting.
How IV NAD⁺ Works
By bypassing digestion and absorption, IV NAD⁺ delivers NAD⁺ directly into circulation. This is fundamentally different from oral supplementation, which relies on digestion, absorption and intracellular conversion.
Practical Considerations for IV NAD⁺
IV NAD⁺ typically requires:
· Access to a clinical environment
· Professional administration
· Scheduled appointments
While IV NAD⁺ may result in short-term increases in circulating NAD⁺, evidence around long-term cellular uptake and sustained outcomes remains limited. Cost, accessibility and practicality are also key considerations for many individuals.
Rather than one approach being inherently “better” than another, these options reflect different philosophies and use cases.
Oral NAD⁺ Precursors (NMN and NR)
· Support the body’s natural NAD⁺ synthesis pathways
· Taken as part of a daily routine
· Regulated as listed medicines when ARTG-listed
· Focus on supporting normal cellular processes over time
IV NAD⁺
· Delivered directly into the bloodstream
· Requires clinical administration
· Typically accessed occasionally rather than daily
· Regulated differently from oral listed medicines
Regulation and Quality in Australia
In Australia, oral supplements such as NMN and NR must be listed on the ARTG to be legally supplied as listed medicines. This ensures:
· Ingredients are permitted for use
· Manufacturing follows Good Manufacturing Practice (GMP)
· Claims stay within approved indications
· Labelling meets Australian regulatory standards
IV NAD⁺ is delivered as a medical or wellness procedure rather than a listed medicine and is regulated under different frameworks.
When deciding how to support NAD⁺ levels, individuals may consider:
· Preference for oral supplements versus clinical procedures
· Desire for daily, ongoing support or occasional intervention
· Importance of regulatory oversight and product transparency
· Lifestyle, schedule and accessibility
Understanding how each option works allows consumers to choose an approach aligned with their preferences and wellbeing goals.
As interest in NAD⁺ grows, several misconceptions often appear:
· “More is always better” – NAD⁺ biology is complex, and balance matters
· “Direct NAD⁺ is always superior” – delivery method does not guarantee sustained cellular support
· “All products are the same” – formulation, regulation and quality standards vary widely
Clear education helps separate biological reality from marketing hype.
NMN, NR and IV NAD⁺ each represent different ways of engaging with the body’s NAD⁺ systems. Each has distinct mechanisms, practical considerations and regulatory contexts.
Within Australia’s regulated supplement landscape, TGA-listed NAD⁺ precursors offer a structured and transparent way to support normal cellular energy production and metabolic function as part of a broader wellbeing approach.
As research into NAD⁺ continues to evolve, interest in NMN, NR and IV NAD⁺ is likely to grow alongside it. A measured, evidence-led understanding ensures decisions are grounded in science, regulation and individual context — rather than trends or hype.
By understanding how these options differ, consumers can navigate the NAD⁺ landscape with greater clarity and confidence.
As interest in NMN and other NAD⁺-related ingredients continues to grow, regulation has become an increasingly important part of the conversation. In Australia, supplements that are supplied as listed medicines are regulated by the Therapeutic Goods Administration (TGA) — a framework designed to protect consumers through quality, safety and transparency.
Understanding what it means for an NMN product to be TGA-listed helps consumers make informed, confident decisions in a crowded and often confusing supplement landscape.
This article explains how regulation works in Australia, why TGA listing matters for NMN products, and how Australians can use this information when choosing supplements.
The Therapeutic Goods Administration (TGA) is Australia’s regulatory authority responsible for overseeing therapeutic goods supplied in Australia.
This includes:
· Prescription medicines
· Vaccines
· Medical devices
· Listed and registered complementary medicines
For supplements such as NMN, the TGA’s role is to ensure products meet defined standards for quality, safety, manufacturing and consumer communication before they can be legally supplied to Australians.
A TGA-listed medicine is one that appears on the Australian Register of Therapeutic Goods (ARTG).
Products listed on the ARTG must meet specific regulatory requirements, including:
· Containing only permitted ingredients
· Being manufactured in facilities that comply with Good Manufacturing Practice (GMP)
· Using approved indications that are supported by evidence
· Meeting strict labelling and advertising requirements
TGA-listed medicines can be identified by an AUST L number on the product label, which allows consumers to verify the product’s listing status on the ARTG.
NMN has attracted significant global attention, particularly within longevity and biohacking communities. As demand increased, many NMN products entered the market through overseas suppliers, often without consistent regulatory oversight.
For Australian consumers, this created uncertainty around:
· Ingredient identity and purity
· Accuracy of stated dosage
· Manufacturing quality
· Compliance with Australian consumer and advertising laws
TGA listing addresses these concerns by ensuring NMN products supplied as listed medicines meet the same regulatory standards as other complementary medicines in Australia.
The inclusion of NMN in products listed on the ARTG represents an important development for the Australian supplement market.
It confirms that NMN has been assessed against Australia’s regulatory framework and can be supplied in listed medicines with approved, evidence-based indications.
For consumers, this milestone provides a clearer and more transparent pathway to accessing NMN products within Australia’s regulated system.
Manufacturing Quality and GMP Standards
One of the most important protections provided by TGA oversight relates to manufacturing quality.
Good Manufacturing Practice (GMP)
All TGA-listed medicines must be manufactured in facilities that comply with Good Manufacturing Practice (GMP) standards. These standards cover:
· Sourcing and verification of raw materials
· Quality control testing
· Batch consistency and traceability
· Storage and distribution
GMP requirements help ensure that listed medicines are produced consistently and meet defined quality specifications from manufacture through to sale.
TGA listing also ensures that product labels are accurate, compliant and not misleading.
For NMN products, this means:
· The ingredient must be correctly identified
· The stated dosage must reflect the amount present
· Labels must not include unapproved or exaggerated claims
This level of transparency supports informed decision-making and allows consumers to understand exactly what they are taking.
In Australia, listed medicines are only permitted to carry indications that fall within the TGA’s approved framework.
For NMN-containing listed medicines, permitted indications relate to supporting:
· Energy production
· Nervous system health
· Reduction of free radical damage to body cells
These indications reflect NMN’s role in supporting normal physiological processes, not in treating or preventing disease.
This structure ensures that consumer communication remains balanced, evidence-based and trustworthy.
The TGA regulates not only what ingredients can be used in listed medicines, but also how those products are advertised.
Advertising controls include:
· Prohibitions on disease and cure claims
· Restrictions on exaggerated or misleading statements
· Requirements for accuracy and clarity in consumer messaging
These safeguards are designed to protect consumers and ensure therapeutic goods are promoted responsibly.
Before NMN became available in listed medicines in Australia, many consumers sourced NMN from international websites. While some overseas products may meet high standards, others may not be subject to the same regulatory oversight.
Potential challenges with overseas products include:
· No confirmation of GMP manufacturing
· Uncertainty around ingredient purity or identity
· Inconsistent dosing
· Limited consumer recourse if issues arise
TGA-listed NMN products provide an added layer of confidence by operating within Australia’s regulatory and consumer protection frameworks.
Access to NMN products supplied locally within Australia offers several practical advantages, including:
· Faster and more reliable supply
· Clear regulatory oversight
· Local accountability and consumer protections
· Compliance with Australian labelling and advertising laws
Local availability also supports transparency across the supply chain, from manufacture to sale.
Consumers can verify whether a product is TGA-listed by:
· Looking for an AUST L number on the product label
· Searching the product name or AUST L number on the ARTG public database
This simple step helps confirm that a product has been listed and meets Australian regulatory requirements.
In a crowded supplement market, trust is built through transparency, accountability and regulation. TGA listing provides a framework that helps consumers navigate complex ingredient categories like NMN with greater confidence.
By choosing listed medicines, Australians can be assured that products meet defined standards for quality, safety and evidence-based communication.
TGA-listed NMN products are not positioned as cures or treatments. Instead, they are regulated to support normal bodily functions such as energy production, nervous system health and cellular protection.
This balanced approach reflects the broader philosophy of Australia’s therapeutic goods framework: supporting health through evidence, transparency and responsible communication.
As interest in NMN continues to grow, understanding the importance of TGA listing becomes increasingly relevant. Regulation provides clarity in a complex market and ensures NMN products available in Australia meet consistent, high standards.
For Australians seeking credible, regulated support for cellular energy and wellbeing, TGA-listed NMN represents an important step forward in quality, transparency and trust.
Over the past few years, NMN (nicotinamide mononucleotide) has become one of the most talked-about ingredients in the global wellness and biohacking space. Closely linked to NAD⁺, a molecule essential for normal cellular energy production, NMN has captured the attention of researchers, health professionals and consumers alike.
As interest in preventative health, vitality and healthy ageing continues to grow, many Australians are asking the same question:
What exactly is NMN — and why is it generating so much interest?
This article explores what NMN and NAD⁺ are, how they function in the body, and why NMN has become a focus of ongoing scientific research into cellular health.
NAD⁺ (nicotinamide adenine dinucleotide) is a molecule found in every living cell. It plays a fundamental role in many biological processes essential for normal health and wellbeing.
One of NAD⁺’s primary functions is its involvement in cellular energy production. Cells require energy to carry out basic processes, and NAD⁺ acts as a key coenzyme that enables nutrients from food to be converted into usable cellular energy.
Beyond energy production, NAD⁺ is involved in:
· Normal metabolic processes
· Supporting enzymes that help maintain cellular function
· Nervous system signalling
· Cellular responses to everyday environmental stressors
Because NAD⁺ is involved across so many systems, maintaining adequate levels is essential for cells to function efficiently.
Research has shown that NAD⁺ levels naturally decline as part of the ageing process. This change is considered a normal physiological phenomenon and is influenced by several factors.
As the body ages:
· Cellular demands for maintenance and repair increase
· Metabolic efficiency may change
· Lifestyle factors such as stress, sleep, diet and physical activity can influence NAD⁺ availability
When NAD⁺ levels decrease, the body must work harder to maintain normal cellular energy production and metabolic balance. This has led scientists to explore nutritional strategies that support the body’s existing NAD⁺ production pathways, rather than attempting to replace NAD⁺ directly.
NMN (nicotinamide mononucleotide) is a naturally occurring compound that plays a direct role in the body’s NAD⁺ synthesis process.
It is found in small amounts in foods such as:
· Broccoli
· Cabbage
· Avocado
· Edamame
Within the body, NMN functions as a precursor to NAD⁺, meaning it acts as a building block the body uses to produce NAD⁺ inside cells.
Rather than acting independently, NMN supports the body’s own biochemical pathways by supplying a compound that can be efficiently converted into NAD⁺ where it is needed.
Given the importance of NAD⁺, it’s natural to ask why it isn’t taken directly as a supplement.
NAD⁺ is a relatively large molecule and does not cross cell membranes easily. When taken orally, it is not absorbed in meaningful amounts, which limits its usefulness as a direct supplement.
For this reason, research has focused on NAD⁺ precursors — compounds the body can absorb and then convert into NAD⁺ internally. NMN is of particular interest because it sits just one step away from NAD⁺ in the body’s primary synthesis pathway.
By supplying NMN, the body can support NAD⁺ production in a way that aligns with its natural biological processes.
Cellular energy production occurs primarily in structures called mitochondria, often referred to as the “energy centres” of the cell. These structures rely on NAD⁺ to convert nutrients into energy that cells can use.
By supporting NAD⁺ availability, NMN plays an indirect but important role in maintaining normal cellular energy production. This foundational process underpins many aspects of everyday health, including:
· Physical energy
· Mental focus
· Overall vitality
Importantly, NMN does not act as a stimulant. Instead, it supports the body’s existing energy-producing pathways, contributing to steady, sustainable energy at a cellular level.
Another area of interest around NMN relates to oxidative stress and cellular protection.
Oxidative stress occurs when free radicals are produced faster than the body can neutralise them. While this is a normal part of metabolism and environmental exposure, ongoing oxidative stress can place strain on cells over time.
NMN is recognised for its role in supporting the body’s natural defences against free radical damage to body cells, which aligns with permitted indications for listed medicines. This support contributes to maintaining normal cellular function rather than treating or preventing disease.
Antioxidant support is often discussed in the context of healthy ageing, as it helps preserve cellular integrity over time.
Interest in NMN has grown alongside broader shifts towards preventative health and long-term wellbeing. Many consumers are now focused on supporting energy, vitality and resilience rather than chasing short-term fixes.
NMN has attracted attention because it targets a foundational biological process — cellular energy production — rather than a specific symptom or condition. This systems-based approach aligns with modern wellness philosophies that prioritise balance, maintenance and normal function.
At the same time, ongoing research into NAD⁺ biology has brought NMN into the spotlight, particularly within academic, longevity and biohacking communities.
Much of the early research into NMN has been conducted in preclinical models, where NMN supplementation has been shown to increase NAD⁺ levels within cells.
Human research is continuing to expand, with studies examining how oral NMN supplementation affects NAD⁺ levels and markers of cellular function. While this research is still developing, it has contributed to growing scientific and public interest.
It’s important to note that NMN is not a medicine for the treatment of disease. Research focuses on its role in supporting normal physiological processes associated with energy production and cellular maintenance.
For a period, NMN was not available in medicines regulated by the Therapeutic Goods Administration (TGA), leading many Australians to source products from overseas without clear assurances around quality or regulatory oversight.
The inclusion of NMN in products listed on the Australian Register of Therapeutic Goods (ARTG) represents an important step in ensuring NMN products supplied locally meet Australian standards for:
· Safety
· Quality
· Manufacturing
· Labelling
For consumers, this provides greater confidence and transparency when choosing NMN products within Australia’s regulated framework.
NMN and NAD⁺ sit at the intersection of nutrition, cellular biology and preventative health. While research is ongoing, growing interest in NMN reflects a broader shift towards supporting the body’s natural systems as part of a long-term wellbeing approach.
As scientific understanding continues to evolve, NMN remains an ingredient of interest for those seeking credible, regulated support for cellular energy and everyday vitality.
Author: Rob Corso
Longevity is the new frontier, and supplements are its gold rush. Everyone’s chasing more energy, more clarity, more years. A life well-lived is about the combination of good habits, a clear purpose, and healthy connection. That’s the foundation. Within that framework, supplements can definitely help.
They can support and elevate your energy, mood, metabolism, brain function, recovery, and more—when used wisely. But effective supplementation requires patience. Supplements work gradually over time, and many can and should be used in cycles. Before adding anything new, consult a healthcare provider. Ideally, get comprehensive testing to establish your baseline and surface deficiencies or imbalances. This helps ensure you’re targeting your wants and needs, not just chasing trends.
Once you start, track your experience. Journal what you notice: changes in energy, focus, sleep, digestion, mood. Supplements work best when you treat the process as an experiment—with data and awareness, not guesswork. You’ll often hear about “stacks”—strategic combinations of supplements designed to support a specific outcome (like better focus or muscle recovery).
Above all, supplementation is about giving your body the raw materials and support it needs to rebuild, repair, and eventually thrive. It already knows what to do—it just needs the right fuel and conditions.
Mitochondria generate the energy that powers your life—from intense workouts to creative thinking. When these metabolic engines function optimally, you experience better endurance, faster recovery, and more consistent mental and physical energy. The supplements in this category support mitochondrial efficiency and protection, helping you maintain peak performance in daily activities while supporting tissue repair and cellular health for long-term vitality.
It is impossible to overstate the importance of optimal mitochondrial function.
Nicotinamide Adenine Dinucleotide (NAD+) is a vital coenzyme that powers cellular energy production, supports DNA repair, and activates longevity-related enzymes like sirtuins. NAD+ levels drop significantly with age, impacting metabolism, mitochondrial function, and resilience to stress.
The evidence: In animal studies, restoring NAD+ improves metabolism, cognition, and stem cell repair. Human trials show NAD+ precursors like NMN and NR effectively raise NAD+ levels and may support muscle and cardiovascular health.
Why it matters: One of the most promising molecules in ageing science. While long-term effects are still being studied, NAD+ restoration is a well-supported strategy for cellular health and vitality. Supplementation is available via IV drip or transdermal patch, or through precursors like NMN and NR.
Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) are NAD+ precursors that support cellular energy production, DNA repair, and mitochondrial function. As NAD+ levels decline with age, restoring them may enhance metabolism, endurance, and cognitive performance.
The evidence: Animal studies show improved insulin sensitivity and physical function. Human trials confirm NAD+ levels rise with supplementation, though clinical outcomes are still developing.
Why it matters: Widely used in longevity protocols. Well-tolerated and promising, though long-term human impact is still being studied.
Ubiquinone (CoQ10) is a key player in mitochondrial energy production and cellular defence. It supports ATP synthesis and protects cells from oxidative stress. Levels naturally decline with age.
The evidence: Improves outcomes in older adults when paired with selenium.
Why it matters: A foundational supplement for mitochondrial health—particularly important for those over 40 or taking statins.
Alpha-Lipoic Acid (ALA) and Acetyl-L-Carnitine (ALCAR) work together to support mitochondrial energy metabolism and reduce oxidative damage. ALA is a potent antioxidant, while ALCAR helps transport fatty acids into mitochondria to be used for energy, especially in high-demand tissues like the brain and heart.
The evidence: Shown to reverse markers of ageing in rodents; small human studies support improvements in cognition and energy.
Why it matters: A classic longevity duo with strong mechanistic rationale. May modestly lower blood sugar—something to monitor for diabetics.
Creatine helps regenerate ATP in muscle and brain cells, supporting both physical strength and cognitive performance. It’s especially helpful in preserving lean mass and energy as we age.
The evidence: Backed by robust human studies showing improvements in muscle mass, recovery, and brain function.
Why it matters: One of the safest, most effective, and most studied supplements for healthy ageing.
Your cells face oxidative challenges daily—from exercise and metabolism to environmental exposures. These supplements support your body’s natural defence systems, helping maintain cellular integrity and function across all tissues. With proper antioxidant balance, you may experience better skin quality, improved exercise recovery, enhanced detoxification, and greater resilience to stress. These compounds help you maintain vitality and function now while supporting healthy cellular ageing.
Omega-3 Fatty Acids (EPA/DHA) are essential long-chain fats found in cold-water fish and algae. They play a critical role in brain health, cardiovascular function, and the regulation of inflammation—making them foundational for healthy ageing and wellbeing.
The evidence: Higher omega-3 levels are associated with improved cardiovascular function, slower cognitive decline, and better triglyceride profiles. Blood tests like the Omega-3 Index can help guide dosing. Most people are deficient.
Why it matters: A longevity essential. Aim for 1–2g of combined EPA/DHA daily from high-quality fish or algae oil. A cornerstone of inflammation and brain support.
Glutathione is the body’s master antioxidant, made in the liver, and is essential for detoxification, immune defence, and protection against oxidative damage. It maintains redox balance and helps neutralise cellular stress that accumulates with age.
The evidence: Levels decline with age. Supplementation supports insulin sensitivity, mitochondrial function, and markers of biological ageing.
Why it matters: A central antioxidant for healthy ageing. Best delivered via liposomal or IV forms, or supported through NAC.
Your metabolic function impacts everything from daily energy levels to long-term resilience. These supplements support efficient glucose handling, energy regulation, and cellular adaptability—helping you feel more energetic, mentally sharp, and physically capable today while also building a foundation for future health. Whether you’re looking to enhance athletic performance, maintain healthy weight, or simply feel more vital, optimising metabolic health offers both immediate and lasting benefits.
Berberine is a plant compound long used in traditional Chinese medicine. It supports blood sugar control, enhances insulin sensitivity, and reduces inflammation—similar to metformin.
The evidence: Human studies show strong effects on glucose, cholesterol, and inflammation.
Resveratrol is a polyphenol found in red wine, grapes, and certain berries. It mimics fasting by activating sirtuins and AMPK, and offers antioxidant and anti-inflammatory support.
The evidence: Extends lifespan in yeast, worms, and some mice. Human trials show mixed results, largely due to poor bioavailability.
These compounds support focus, memory, stress resilience, and mental clarity—helping you stay sharp, creative, and emotionally balanced. They protect your neurons, neural connections, and brain structures from damage while supporting the neurotransmitter systems that govern mood, memory, and focus.
Lion’s Mane is a medicinal mushroom that stimulates nerve growth factor (NGF), supporting the regeneration of neurons, cognitive performance, and long-term brain health.
The evidence: Improves memory and focus in older adults. Animal studies show it promotes neural repair and growth.
Why it matters: A well-tolerated, safe, natural nootropic with neuroprotective benefits. Best taken consistently to maintain effects.
So, can supplements help? Yes, when approached and executed properly. The right supplements, in the right context, can elevate how you feel, help you reach specific goals, and give your system the boost it needs. But supplements are just that—supplementary. They’re meant to support or enhance systems that are already working well, not replace the fundamentals. Supplements aren’t shortcuts; they’re tools. Use them wisely, and they can help you feel better, think clearer, and recover faster.
It is important to note that supplement quality is largely self-regulated. You’re trusting the manufacturer to do the right thing—and not all of them do. Stick with brands that test for purity and potency.
Even when you’re taking the right stuff, results take time. Building an effective stack can get expensive fast. Some regimens can have you swallowing a small pharmacy every day. So be thoughtful. Know what you’re taking and why. Start small. See how you feel. When you get it right, you can feel the difference.
Disclaimer: This newsletter is provided for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used for diagnosing or treating a health condition, and those seeking personal medical advice should consult a qualified healthcare professional.
Author: Rob Corso
There is a living, dynamic universe within you. A biological ecosystem so sophisticated that it influences everything from your mood and metabolism to your immune system and mental health. It is a pillar of wellness that scientists are only beginning to understand. That understanding will potentially revolutionise how we think about human health.
Every second of every day, trillions of microscopic bacteria, fungi, and other microorganisms are dancing around in this internal universe. These vast communities of microbes (primarily residing in your large intestine) form what scientists call . . .
What was once considered solely digestion is now recognised as a complex and highly synchronised internal world essential to physical health and mental wellness.
The gut’s microbial community is so vast, complex, and influential that it essentially behaves as its own autonomous organ—a second brain, if you will.
This topic can be dense and is often discussed using technical biological terms. While much of the research is generally consistent, some discrepancies exist across various studies. Our aim is to distil and present the information as clearly and accurately as possible.
By now, you’ve likely heard the phrase “gut microbiome” quite a bit. Perhaps you know about probiotics and maybe even prebiotics. Even without knowing exactly what it is or how it works, you know the gut microbiome is important.
Here are some wild facts you should know about the gut:
There are more bacterial cells in your body than human cells (40 trillion vs. 30 trillion).
There are at least 1,000 distinct species of bacteria (likely many more) living in the gut. Each performs different tasks in the body. Not all bacteria are bad.
The gut microbiome weighs approximately 2-5 lbs (about the weight of a pineapple).
Around 90% of the body’s serotonin, our body’s “happy” chemical, is produced in the gut.
Your gut contains significantly more neurons than your spinal cord.
About 70-80% of the body’s immune cells are located in your gut’s lymphoid tissue and interact with your microbiome.
Understanding how the gut microbiome affects your health requires exploring three fundamental areas of influence: metabolism, immunity, and the gut-brain connection.
Your gut microbes transform the food you eat into energy and compounds your body can use. They break down fibre into short-chain fatty acids, which nourish your intestinal cells, regulate inflammation, improve insulin sensitivity, and regulate blood sugar levels. Our gut bacteria produce several essential vitamins that our bodies cannot synthesise on their own. The primary vitamins produced include vitamin K and various B vitamins.
Your gut microbiome is a sophisticated training ground for your immune system. From birth, microbes help immune cells distinguish between what’s friendly and what’s dangerous. Our earliest exposure to microbes—through vaginal delivery, breast milk, and skin-to-skin contact—helps set up our immune system’s baseline.
About 70–80% of the body’s immune cells reside in the gut wall, where they maintain the gut barrier, prevent “leaky gut,” and determine what to attack. Leaky gut occurs when the gut barrier becomes permeable, allowing harmful substances into the bloodstream. This triggers something called endotoxemia, a series of inflammatory responses throughout the body.
The relationship between microbes and immunity is so fundamental that scientists now believe many modern immune disorders, allergies, and chronic inflammation may stem from disrupted microbial communities.
“How is it that the bugs in your gut are connected to your wellbeing? I could go on and on. Everything is connected to the microbiome. How does that make sense given our paradigm? If you are going to your psychiatrist with low mood are they saying, let me look at your poop? Well, they should, okay, literally they should.”
—Dr. Mark Hyman, Eudēmonia Summit 2024
So why do they call it your second brain? For three main reasons:
The gut and brain are connected through neural, hormonal, and immune pathways, with a superhighway called the vagus nerve as a key component in the bidirectional relationship between these organs.
Second, your gut has its own nervous system, called the enteric nervous system (ENS). It’s often referred to as the “second brain” because it can operate independently of our first brain. It’s an autonomous and self-sustained system, and the ENS has many of the same neurons and neurotransmitters that our first brain has.
Third, and maybe most important, is the neurochemical influence, by which the gut microbiome can profoundly influence our mental and emotional health. Because of the gut–brain axis, emotional and cognitive centres of the brain are directly linked to intestinal functions. This helps explain why digestive health often correlates with mental health.
Research has shown that microbiome disruptions may contribute to anxiety, depression, and even neurodegenerative conditions. Conversely, psychological stress can alter your gut microbiome, creating a feedback loop between mind and microbes. The connection is so strong that scientists have found that transplanting gut bacteria from people with depression into healthy rats can actually make the rats exhibit depressive behaviours. And studies have shown that people with depression or anxiety often have a less diverse microbiome.
In short, a healthy gut could trigger better moods and better brain function.
Your gut microbiome is shaped by a complex interplay of factors—from the food you eat to the environment you live in—working together to influence your overall health and well-being.
Insufficient fibre and excessive consumption of highly refined carbohydrates, processed foods, and refined sugars are among the most common gut disruptors. What you eat has such a profound impact on your gut that your microbes can respond rapidly to dietary changes, often within 24-48 hours. However, establishing a stable and healthy microbiome composition requires consistent, healthy dietary habits.
Chronic stress and poor sleep have a negative impact on your gut microbiome, as does a sedentary lifestyle that doesn’t prioritise regular exercise.
Heavy reliance on certain prescription drugs all contributes to gut dysregulation. Antibiotics can be particularly detrimental, as they significantly alter the gut microbiome by killing both harmful and beneficial bacteria indiscriminately.
Everything from where you live, the cleaning products you use, and the air you breathe has an impact. The chemicals, pollutants, and pesticides you’re exposed to all influence the stability of your microbiome.
Vaginal birth, breast milk, and avoiding early exposure to antibiotics positively shape your initial microbiome.
Gut imbalance can manifest in surprising ways, affecting not just digestion but your immune system, mood, skin, energy levels, and more. Here are some key warning signs to watch for.
Digestive Issues: irregular bowel movements, bloating, gas or abdominal discomfort, acid reflux, or heartburn
Immune System Issues: recurring infections, slow wound healing, frequent colds, severe seasonal or food allergies, chronic inflammation
Cognitive Signs: mood changes, brain fog, , irritability
Skin Problems: acne, eczema, rosacea, dry or itchy skin, rashes
Unusual Fatigue: low energy that doesn’t improve with rest, difficulty sleeping
Food Sensitivities: new sensitivities to previously tolerated foods, gluten or dairy intolerance emerging
Hormonal Indicators: irregular menstrual cycles, worsening PMS symptoms, weight fluctuation
It cannot be overstated how important a healthy gut microbiome is to your overall wellness. Disruptions in gut microbiota and gut permeability have been connected to both the causes and effects of a wide range of conditions and diseases, some of which may surprise you.
So what can we do to nurture our gut health and support a balanced microbiome?
Food is mood. This might sound ambitious, but research from the American Gut Project suggests aiming to eat 30 different plant foods weekly. Each colour represents different compounds that feed diverse bacterial communities. Focus on fruits, vegetables, tubers, whole grains, nuts, seeds, and legumes.
This will also get you lots of fibre, which is very important for colon health. A recent study found that higher total dietary fibre intake was associated with a significantly reduced risk of colon cancer. As a rule, aim for 30g of fibre per day.
Fermented foods promote and add healthy bacteria to your gut. These foods include yogurt with live cultures, kombucha, kimchi, sauerkraut, tempeh, pickles in brine, sourdough bread, and miso.
Probiotics are “good” bacteria that live in and promote a healthy gut, and are found in the fermented foods listed above. Prebiotics are fibres from plants that serve as food for the probiotics in your gut. We want a diet that includes both, but there are also ways to supplement these.
This is ubiquitous health advice, but it is important to mention that excess sugar and processed foods can promote the growth of harmful bacteria and cause inflammation. In particular, foods high in artificial sweeteners and emulsifiers can alter microbial populations and intestinal barriers.
Staying hydrated helps maintain the gut’s protective barrier, which aids in preventing conditions like leaky gut.
Stress does all kinds of wacky things to your gut. It impacts digestion, harms the gut’s protective lining (leading to leaky gut), and disrupts the communication of the gut-brain axis, which can lead to mental health issues. Regularly practising meditation, yoga, or anything else that relieves stress in a healthy way is important.
Aerobic work, strength training, and restorative movement all promote microbial diversity and enhance gut barrier function. Incorporating a balance of brisk walking or jogging or cycling, yoga or pilates, and strength training is a good regimen for a healthy gut—and a generally healthy life.
Incorporating a 10-minute walk after meals has been shown to reduce blood sugar levels up to 35%. Stable blood sugar is important for maintaining a healthy gut microbiome, and it lowers stress and reduces gas and bloating.
Gardening exposes you to a diverse range of microorganisms through your skin, which can support immune function and improve mood. Plus, time outdoors increases vitamin D levels through exposure to sunlight, which also supports gut barrier integrity.
A diet that prioritises a wide range of plants and incorporates fermented foods should be your primary focus.
You should always consult with a doctor and consider getting tested to understand the health of your gut.
When choosing supplemental probiotics, select products with multiple strains and rotate brands periodically to introduce different beneficial species. Also, certain strains may aid in digestive health, while others might support immune function. Consult a healthcare professional to identify the strain best suited to your health needs, as effects vary from person to person.
You can also consider introducing supplemental prebiotics, but start slowly to avoid digestive discomfort. Some use natural antimicrobial compounds berberine occasionally to help maintain microbial balance. Finally, Vitamin D may increase microbial diversity, help regulate intestinal barrier integrity, and support immune function in the gut.
Exciting new treatments and technologies are emerging that could revolutionise how we approach gut health and overall wellness.
This concept is being actively researched, although it’s still in early stages. It uses genetically engineered probiotics for tailored interventions based on individual characteristics and needs.
Advanced sequencing technologies are used to map individual gut microbiomes. The development of AI-powered platforms for personalised recommendations is an active area of research and commercial development.
Wearable technologies are offering unprecedented insights into digestive system functioning with non-invasive gut health tracking.
Simply put, our mental health and physical well-being are dependent on a well-functioning, balanced, and diverse microbiome. It’s our second brain, and nurturing this internal ecosystem is one of the most powerful investments we can make into our long-term health.
That health is a direct reflection of our lifestyle, environment, and choices. By supporting this invisible ecosystem, we’re investing in our overall health and well-being in ways that science is only beginning to understand.
As you embark on your journey to optimise your gut health, remember that your microbiome responds best to consistent, nurturing care. Small, daily choices accumulate to create sustainable habits and significant changes. Listen to your body, stay curious about new research, and approach this complex internal world with curiosity and patience.
Disclaimer: This newsletter is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.
Author: Rob Corso
Some parts of it are measurable metrics: numbers you can track over time, like VO₂ max, HRV, and resting heart rate.
Others are functional fitness tests: physical abilities you can lose without realising it, like grip strength, walking speed, and balance.
Both are critical.
Metrics tell you how your internal engine is performing. Tests tell you how the machine moves through the world.
But what exactly should we be measuring and working to improve?
In this issue, we’ll separate the key longevity indicators into two categories:
• Physiological Metrics: Measurable biological values like VO₂ max and HRV
• Physical Performance Benchmarks: Functional tests like push-ups and dead-hangs
The internal, physiological metrics offer a powerful snapshot of your body’s current and future health. But those numbers aren’t the whole story. To predict how well you’ll function as you age—your physical performance might matter just as much.
Let’s dig in.
These core biological measurements are some of the strongest predictors of how long—and how well—you’ll live. They’re the vital signs of longevity, and you can track and improve every one of them.
(Cardiorespiratory Fitness)
VO₂ max measures the maximum amount of oxygen your body can utilise during intense exercise. It’s a marker of aerobic capacity and cardiovascular fitness.
VO₂ max is arguably the strongest predictor of longevity.
How to Test It: The gold standard is a laboratory cardiopulmonary exercise test (CPET), where you wear a mask that measures oxygen consumption while exercising to exhaustion. Fitness watches estimate VO₂ max using heart rate data and exercise intensity. The Rockport Walking Test offers a low-tech alternative: walk 1.6 kilometers (1600 meters) as fast as possible, record your time and heart rate at completion, then calculate your VO2 max using standardised formulas available online. Alternatively, try the The Cooper Test—running as far as possible in 12 minutes—is another widely used field test with reliable estimation formulas.
Use a standardised formula to estimate your VO₂ max based on total distance. Aiming for 2,500 metres or more puts most middle-aged adults in the 75th percentile or above, with elite athletes often exceeding 3,200 metres. Even modest improvements from baseline can significantly reduce mortality risk.
How to Improve: Zone 2 cardio training (working at about 70-80% of maximum heart rate) is the most efficient approach, ideally for 3–5 hours weekly. Add 1–2 weekly HIIT sessions for even greater gains. Many people see a 10–15% boost in a year.
maintaining found that higher muscle mass is associated with a 20% lower risk of all-cause mortality, independent of fat mass or BMI, highlighting the importance of maintaining lean tissue.
How to Test It: The gold standard for measuring muscle mass is a DEXA (Dual-Energy X-ray Absorptiometry) scan, which provides detailed body composition data, including lean muscle mass, fat mass, and bone density. Bioelectrical impedance analysis (BIA) scales, which send a small electrical current through the body to estimate muscle mass, are a convenient alternative. These smart scales can track changes over time.
Where You Should Be: While specific muscle mass targets vary by height and frame size, being in the top 50% of your age group is a strong start. Top 25% is ideal. After 30, people typically lose 3–5% of muscle per decade without intervention.
How to Improve: Lift weights 2-3 times weekly, focusing on compound movements that engage multiple muscle groups. Proper protein intake supports this training, too. And as we keep seeing, adequate sleep helps, as it supports recovery.
HRV reflects the variation in time between heartbeats and indicates how well your nervous system handles stress and recovery and is an excellent daily indicator of overall physiological balance.
Where You Should Be: There is no universal benchmark for HRV, as it varies significantly between individuals based on age, fitness level, and genetics. The key is to establish a personal baseline and track trends over time. Higher HRV generally means better fitness and resilience.
How to Test It: The most accessible way to measure HRV is through wearable devices that track fitness data.
How to Improve: Regular Zone 2 training, as well as strength training, has been shown to boost HRV. Meditation, breathwork, adequate sleep, sauna and cold plunge, and cutting back on alcohol all positively impact HRV.
Resting heart rate is exactly what it sounds like: the number of times your heart beats per minute when you’re completely at rest. It’s best measured first thing in the morning before getting out of bed. A lower RHR usually means a stronger, more efficient heart.
Where You Should Be: A resting heart rate below 70 bpm is good, with below 60 bpm considered excellent for the general population. Elite endurance athletes often have resting heart rates in the 40s, though this level isn’t necessary for longevity benefits. The key is maintaining a lower RHR as you age, rather than allowing it to drift upward.
How to Test It: Count your pulse for 60 seconds upon waking or use a wearable that tracks it overnight. For the most reliable results, take measurements at the same time each day, ideally after a full night’s sleep and before any caffeine consumption.
How to Improve: The most effective way to lower RHR is consistent aerobic exercise, particularly Zone 2 cardio. Three to four 30-minute sessions weekly can reduce RHR by 5–10 bpm within six months. Improving sleep quality, managing stress through meditation or breathwork, and maintaining proper hydration will help. Limiting stimulants like caffeine and reducing alcohol consumption also help optimise RHR.
These real-world tests don’t just measure fitness—they predict how well you’ll move, age, and maintain independence over time. They reveal what’s happening beneath the surface, long before symptoms show up.
Where You Should Be: For men, above 40kg is excellent; for women, above 25kg. While age-adjusted norms exist, stronger is better—aim for the top 25% in your age group. More important than absolute numbers is preventing the decline that typically occurs with age.
How to Improve: While specific grip strengthening tools can help, compound movements that challenge grip indirectly often yield better results. Deadlifts without straps, farmer’s carries, pull-ups, and dead hangs are particularly effective. For a simple daily practice, hanging from a pull-up bar for an accumulated time of 2–3 minutes daily has shown remarkable benefits for both grip strength and shoulder health.
A 2011 JAMA study found that people who walk faster than 1.2 meters per second (2.7 mph) live significantly longer than slower walkers.
Where You Should Be: 1.2 m/s is the benchmark—that’s 400 meters (a quarter mile) in under 6 minutes at a natural pace. Speeds above 1.4 m/s are linked to even better longevity outcomes.
How to Improve: Leg strength training (particularly squats, lunges, and hip hinges) provides the foundation. Regular walking practice at a slightly faster pace helps. Many find that rucking—walking with a weighted backpack—is effective for faster natural walking speeds. Balance exercises also contribute to more confident, faster walking.
Where You Should Be:
Men:
• 40+ push-ups: Excellent
• 20–40 push-ups: Good
• 10–20 push-ups: Moderate risk
• <10 push-ups: Higher risk
Women:
• 30+ push-ups: Excellent
• 15–30 push-ups: Good
• 5–15 push-ups: Moderate risk
• <5 push-ups: Higher risk
How to Improve: If you can’t yet do standard push-ups, build up gradually: start with wall push-ups, then move to incline push-ups before progressing to the floor. If you’re already doing standard push-ups, try the “grease the groove” method—multiple sets throughout the day, stopping well before failure. To advance further, add weight or use handles to increase range of motion with deficit push-ups.
A dead hang is the ability to hang from a pull-up bar with arms fully extended for a prolonged period. It tests grip strength, shoulder stability, and upper back engagement. Dr. Peter Attia includes the 2-minute dead hang in his “Centenarian Decathlon”—his framework for training the body to thrive into one’s 90s and beyond. That’s helped establish the dead hang as a practical benchmark in the modern longevity toolkit.
Where You Should Be: A 2-minute dead hang signals excellent shoulder and grip health. Beginners can aim for 30 seconds as a starting point.
How to Improve: Do 3–4 max-effort hangs per session, 3x/week, resting fully between sets. If hanging is too difficult at first, use a bench to offload weight. Active hangs (shoulders engaged, not passive) build strength faster. Once you can hang for 90 seconds, add weight with a vest or dip belt to keep progressing.
Another of Dr. Attia’s assessments, this isometric hold tests lower body endurance and core stability—factors closely linked to functional independence with aging.
Where You Should Be: Dr. Attia recommends being able to hold a proper wall sit (back against wall, thighs parallel to floor, knees at 90 degrees) for 2 minutes. It’s difficult, so 45–60 seconds is a common starting point.
How to Improve: Practice 3 sets of your max hold, 3x per week. Add 5–10 seconds each week. Once you hit 90+ seconds, hold lightweight at your chest for added difficulty. Squats and lunges also build the strength needed for longer wall sits.
The farmer’s carry is a simple but powerful test of your ability to walk while holding heavy weights in each hand. This test combines grip, core, and full-body endurance—essential for everyday strength.
Where You Should Be: Carry your body weight (split between both hands) for 2 minutes. A solid starting point: 50% of your body weight for 1 minute.
How to Improve: Start by finding the heaviest weight you can carry for 1 minute. Train with 70–80% of that load, gradually increasing time or weight. Do 2–3 sessions per week. Pair with deadlifts or pull-ups for faster gains.
This test assesses your ability to move from standing to sitting on the floor and back up with minimal support—a real-world measure of strength, balance, and coordination.
Where You Should Be: The standardised version of this test uses a 10-point scale, deducting one point each time a hand, arm, or knee is used for support.
How to Improve: Practice the movement daily. Support it with deep squats, hip and ankle mobility work, core training, and balance drills. Even simple habits like regularly sitting on the floor can help train the mobility required.
Where You Should Be: Hold for at least 10 seconds with eyes open and hands on hips. Better still: 30+ seconds with eyes open, or 10+ seconds with eyes closed. You’ll be surprised at how challenging this can be.
How to Improve: Practice daily—stand on one leg while brushing your teeth or waiting for coffee. Add single-leg deadlifts, pistol squats, or unstable surface work. Tai Chi and yoga are excellent long-term balance builders.
Lower body strength is perhaps the most critical physical attribute for maintaining independence with age. A 2014 American Journal of Medicine study identified leg weakness as a primary risk factor for frailty and loss of mobility.
Where You Should Be: While there’s no single standardised test, good benchmarks include:
• Ability to perform 20+ proper bodyweight squats with good form
• Ability to ascend stairs without using handrails
• Ability to rise from a chair without using arms for assistance
• For those who strength train, deadlifting 75–100% of bodyweight for multiple repetitions
How to Improve: Base your training on squats, lunges, step-ups, and deadlifts. Beginners can start with bodyweight work; progress gradually using weights and resistance. Train legs 2–3 times weekly with proper recovery.
These metrics and benchmarks don’t exist in isolation. Improve one, and you often improve many.
These are the fundamentals that build your physiological signature for aging well.
Zone 2 cardio raises VO₂ max, lowers resting heart rate, and brings your nervous system into balance. Even a little daily mobility work makes you better at walking, balancing, and getting off the floor.
If you’re just starting out, the formula doesn’t need to be complicated:
• Lift weights 2–3 times a week—focus on big, compound movements.
• Do 3+ hours of Zone 2 cardio, broken up however you need.
• Stretch, move, or mobilise daily—even 5 minutes counts.
• Get serious about sleep. It underpins everything else.
Master the basics. They give you something numbers rarely offer: clarity.
You’ll know what’s working. You’ll know where to focus.
And the payoff ismore energy, less pain, better moods, and the quiet confidence of a body that can still do what you ask of it.
We’re living longer than ever. If you start now, you can build a body that can carry you farther than you’d imagine.
Disclaimer: This newsletter is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.
Source: Eudēmonia Summit
Author: Rob Corso
It’s your body’s surveillance network, inflammation modulator, and recovery crew all rolled into one. Your immune system shapes how you age, how quickly you recover, how you sleep, your internal and external inflammation, and even how well your brain works.
It’s one of those things that you forget about when it’s working well. But when it doesn’t, there’s nothing else you think about.
The good news is you can train it. Modulate it. Improve it. Of course, it boils down to what most things boil down to: good habits.
Just about every issue we’ve published touches on immunity.
Let’s explore the full spectrum of immune health: what strengthens it, what sabotages it, and how to make yours more intelligent over time.
Your immune system is exactly that—a system. It’s a distributed network made up of cells, tissues, and signals that span nearly every part of your body, from bone marrow and the gut to your skin and lymph nodes.
There are two main arms:
• Innate immunity is your first responder. It acts fast and broadly. It doesn’t care what the invader is; it just wants it gone. Think of inflammation, fever, and the mobilisation of white blood cells for cuts and bruises.
• Adaptive immunity is your specialist team. It learns from past encounters and remembers pathogens for years or even decades. It creates antibodies and immune memory (via T-cells and B-cells) to respond more efficiently to future threats. This is why, for instance, you typically get chickenpox only once. Your adaptive immune system filed that threat away in its permanent memory bank.
These two arms work together. Ideally, innate immunity holds the line while adaptive immunity gears up a specific defence.
But here’s the nuance: A healthy immune system isn’t one that’s always “strong.” It’s one that’s well-regulated. It knows when to act and when to stand down.
With age, immune responses get slower and less precise This decline is called immunosenescence.
Much of what we call “aging” is really this slow drift into immune dysfunction. Understanding how the system works is the first step to supporting it intelligently.
The real foundation of immune resilience isn’t found in pills and powders; it’s built from your daily habits. Sleep, food, movement, stress, relationships, and gut health are what create the conditions for a responsive, regulated immune system.
You don’t need to be perfect. But consistency compounds, and that’s the basis of a strong anything.
Sleep is when your immune system does its most important work. During deep sleep, your body produces cytokines that fight infection and inflammation, while your brain’s glymphatic system clears metabolic waste.
Your immune system runs on a circadian rhythm, with key immune cells rising and falling in sync with your sleep-wake cycle. Sleep is so critical to immune function that those who sleep less than 6 hours nightly are 4x more likely to catch a cold.
Growth hormone, released during deep sleep, stimulates immune cell production. Memory T-cells and B-cells consolidate their “training” during sleep. Sleep also reduces natural killer cell activity by 72% with just one night of 4-hour sleep.
→ The Sleep Issue breaks down exactly how to get deeper sleep and stronger immunity.
You are what you eat. And your immune system is metabolically expensive, meaning it requires specific nutrients to function optimally.
Micronutrients like vitamins C, D, zinc, and selenium are essential to immune cell function. Fibre feeds gut bacteria, which in turn regulate immune balance. Too many ultra-processed foods can trigger low-grade inflammation.
Eat whole foods. Emphasise plants, legumes, nuts, and fermented items. Eat foods full of polyphenols, vitamins and flavonoids. Think nourishment, not restriction.
Exercise is one of the most powerful immune modulators available. Regular movement increases circulation, helping immune cells patrol your body more effectively, while also reducing chronic inflammation.
Exercise enhances immunity by increasing production of antibodies and white blood cells; raising body temperature during and after, which may help fight infections; reducing stress hormones that suppress immune function; and improving sleep quality.
→ Guess what? We did an entire issue on fitness for longevity.
Acute stress can be helpful. Chronic stress, not so much. When stress hormones like cortisol remain elevated, they suppress immune function and increase inflammation.
Chronic stress also shortens telomeres, accelerating cellular aging. Daily stress hygiene matters: breathwork, meditation, nature walks, creative time. Even a few deep breaths can shift your state.
Roughly 70% of your immune system lives in your gut. The microbiome helps regulate inflammation, train immune cells, and maintain tolerance.
Feed it with fibre, polyphenols, and fermented foods.
Humans are inherently social creatures, and meaningful relationships actually boost immune resilience. Socially connected people have stronger antibody responses to vaccines, and social support is shown to reduce stress hormones.
Emerging research suggests that periodic fasting may help “reset” the immune system by promoting autophagy—the cellular cleanup process that removes damaged components.
Fasting can reduce chronic inflammation, promote regeneration of immune cells, clear senescent (aged) cells, and improve metabolic health, which supports immune function.
But be careful, extreme or prolonged fasting may be detrimental to immune function.
Both heat and cold exposure create beneficial stress that strengthens your immune system through hormesis—the process where mild stressors make you more resilient.
Sauna use has some of the most compelling research for immune enhancement and longevity. Regular sauna sessions create beneficial heat stress that strengthens your immune system
While a healthy diet should provide most nutrients, certain supplements may support immune function, especially as we age:
• Vitamin D3 boosts your immune system by activating pathogen-fighting cells and reducing harmful inflammation. Without it, your defences stay sluggish and overreactive.
• Omega-3 fatty acids support anti-inflammatory processes and immune cell membrane function
• Probiotics may help maintain gut barrier function and immune balance.
• Prebiotics strengthen immunity by feeding gut bacteria that produce short-chain fatty acids, which calm inflammation and help regulate immune responses. A healthier gut means a smarter, more balanced immune system.
• Magnesium supports over 300 enzymatic reactions, including those involved in immune function.
Always consult healthcare providers before starting supplements, especially if you have health conditions or take medications.
Meditation isn’t just about stress relief—it’s one of the most scientifically validated ways to directly enhance immune function. Recent research shows that mindfulness meditation produces measurable changes in immune system activity, including reduced inflammation markers and increased immune cell function.
A groundbreaking University of Florida study found that just eight days of intensive meditation caused robust activation of the immune system
One of the simplest yet most overlooked immune practices is how you breathe. Your nose isn’t just for smelling—it’s a sophisticated filtration and immune enhancement system.
Nasal breathing activates multiple immune benefits including natural air filtration through nasal hairs and mucous membranes that trap pathogens, nitric oxide production with powerful antimicrobial properties, and air conditioning that warms and humidifies incoming air.
Practice conscious nasal breathing during daily activities, consider mouth taping at night if you’re a chronic mouth breather (consult a healthcare provider for sleep apnoea concerns), and try alternate nostril breathing exercises for 5–10 minutes daily.
Watch for these warning signs that your immune system may be compromised:
• Getting sick more than 3 times per year
• Infections that are unusually severe or long-lasting
• Slow wound healing
• Persistent fatigue despite adequate sleep
• Frequent digestive issues
• Skin problems like eczema or frequent breakouts
• Allergies that are worsening or new food sensitivities
Your immune system is writing your health future with every choice you make today.
Unlike some aspects of aging, immune resilience isn’t fixed or fated. It’s adaptive. Forgiving. And remarkably responsive—even decades into life.
The immune system rewards consistency. Not perfection.
It remembers what you teach it. T-cells trained now will still be smarter years from now. Gut diversity you build this season becomes a living archive of defences for later.
Even better? It’s never too late to begin.
The goal isn’t to avoid every illness. The goal is to build a body that knows how to recover.
That’s what a strong immune legacy looks like: not fragile and reactive, but calm, capable, and prepared.
Disclaimer: This newsletter is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.
Source: Eudēmonia Summit
Author: Rob Corso
There’s one thing you (hopefully) do every day that’s the most transformative tool in health and wellness. It isn’t a supplement, workout or meditation. It’s the most potent biological upgrade available to you every single day—your most dynamic recovery tool designed to recharge your brain, rebuild your body, and optimise your health from the inside out.
Sleep is fascinating. Did you know it does all of this?
• Removes dangerous toxins from your brain
• Reboots and charges your immune system
• Cleans and repairs your cells
• Balances your hormones
• Organises your memories
• Improves cognition and performance
Poor sleep is linked to a myriad of physical and mental health problems, from chronic illness and heart disease to anxiety and depression. Sleep and mental health have a bidirectional relationship: poor sleep can worsen mental health conditions, while anxiety and depression often disrupt sleep patterns.
The difference between the amount of sleep you need and what you get (called “sleep debt”) accumulates like credit card debt. You’ll eventually have to pay—and with interest. Even missing 1–2 hours per night creates a deficit so significant that it can take weeks to fully reverse the negative impacts. That’s why it’s crucial to take sleep seriously: of all the longevity practices and wellness strategies, high-quality sleep is the most impactful way to protect your health and wellbeing.
Yet for many, it remains elusive and irregular. Below we’ll explore:
• How sleep works
• Why it’s so important
• What the experts have to say
• Strategies to optimise your sleep
Before we dig into the strange magic about sleep, it’s important to note that there’s still a lot we don’t know. The relationship between sleep, consciousness and brain function remains a fascinating area of ongoing research. However, decades of scientific study have given us valuable insights into how sleep works and its crucial role in our health.
When you fall asleep, your body enters into a highly organised sleep routine cycling between Non-Rapid Eye Movement (NREM) Sleep—which accounts for 75–80% of sleep—and Rapid Eye Movement (REM) Sleep.
NREM sleep has three stages.
N1: Light Sleep
Your body starts to relax and brain activity slows, entering the gateway to deeper sleep.
N2: Intermediate Sleep
Your heart rate slows and your brain activity changes, producing sleep spindles. These short bursts of rapid brain activity play a key role in long-term memory consolidation and blocking out external distractions.
N3: Deep Sleep
In the most restorative phase of sleep, muscles are repaired, growth hormones are released, and your immune system gets a serious boost. N3 is vital for clearing out waste, like a power wash for the brain.
The glymphatic system flushes out toxins and metabolic byproducts that build up during the day—compounds strongly associated with cognitive issues and neurodegenerative diseases like Alzheimer’s or dementia. Without sufficient deep sleep, this cleaning process is impaired, leading to a gradual accumulation of harmful substances over time.
REM sleep is where things get really interesting.
REM is the most mysterious phase of sleep and the interval when your brain is most active. This is when you dream, organise and file memories, process emotions, and strengthen creative connections.
During this phase, your eyes dart back and forth beneath your closed eyelids, while your body remains mostly paralysed to prevent you from acting out your dreams.
Memory Consolidation and Learning
REM is critical for procedural and long-term memory (learning how to perform tasks) and emotional memory (sorting through the day’s experiences, deciding what to keep and what to discard). New neural connections are formed and strengthened during REM, making it essential for problem-solving, creativity, and neuroplasticity.
Emotional Processing
REM sleep helps process and “digest” emotions—especially negative ones like fear and anxiety—by reactivating emotional memories in a safe, dreamlike environment. This enables the brain to neutralise their intensity, making emotional challenges easier to handle.
Creativity and Problem-Solving
The chaotic, nonlinear nature of REM dreams fosters out-of-the-box thinking, helping the brain make novel connections. That’s why people often wake up with new ideas or solutions to problems they struggled with the day before.
REM sleep is yoga for the brain, ensuring it remains adaptable, flexible and pliable. Without a sufficient amount, you’ll have lower emotional resilience, impaired learning, weakened creativity and overall cognitive decline.
These cycles repeat every 90 minutes, getting shorter as the night progresses. Deep sleep dominates early on, while REM sleep lengthens toward the morning. This aligns with the body’s circadian rhythm, emphasising physical restoration earlier in the night, and cognitive and memory consolidation later on.
So how much do you need? One to two hours of REM sleep and 1–3 hours of deep sleep per night is optimal.
The pattern and quality of sleep (our “sleep architecture”) changes significantly throughout our lives.
• Newborns spend up to 17 hours sleeping in short bursts, with about 50% of their sleep time in REM, which is crucial for their rapidly developing brains.
• Children and teenagers need more sleep than adults (8–10 hours) and naturally tend toward later bedtimes due to shifts in their circadian rhythm during puberty.
• Adults settle into more stable patterns, but women’s sleep needs often fluctuate with hormonal changes during menstruation, pregnancy and menopause.
The scientific consensus is that, regardless of gender, most adults need 7–9 hours of sleep per night. As we age, sleep becomes lighter and more fragmented, with less time spent in deep sleep stages. This is why older adults might sleep the same number of hours but feel less rested, making sleep hygiene practices increasingly important.
There is evidence that some individuals may need less sleep. Some people have a genetic mutation (DEC2) that allows them to function normally on just 4–6 hours of sleep. However, these cases are rare.
Regardless of your age and gender, it’s clear that the quality and efficiency of your sleep is paramount. That’s why we’re here to help you optimise sleep to the best of your ability.
So what do the experts say?
At the first Eudēmonia Summit, we were joined by some of today’s foremost sleep experts: Dr Michael Breus (The Sleep Doctor); longevity pioneer and sleep athlete Bryan Johnson; sleep coach Jack Dell’Accio; and popular neuroscientist and podcaster Andrew Huberman.
Like anything worth doing, high-quality sleep requires a commitment to good habits. Below are some principles and strategies—researched and recommended by our experts—that are essential for improving sleep.
1. Maintain a Consistent Sleep Schedule
All sleep experts emphasise the importance of maintaining regular bedtimes and wake times, even on weekends, to align with the body’s circadian rhythm. Pick a bedtime and stick to it. Bryan Johnson says, “Your bedtime is your most important appointment today, and every day.”
2. Exercise Earlier in the Day
Exercise and sleep create an effective flywheel, as one boosts the other. Regular exercise primes your body for restful sleep, and quality sleep prepares your body for physical strain. A balance of strength training (which enhances deep sleep) and aerobic activity (which improves sleep latency and duration) is ideal. But no matter what you do, experts agree that you should finish workouts at least a few hours before bed to prevent overstimulation. Early workouts align more with our circadian rhythm.
3. Avoid Caffeine and Alcohol
Avoid caffeine and any other stimulant for at least 6–8 hours (more if you can) before bed. Though some people metabolise caffeine faster than others, see if it has an impact on your sleep by experimenting with your timing. Limit or eliminate alcohol in the evening, as it disrupts the sleep cycle. Though alcohol may help you fall asleep, it damages your sleep quality.
4. Stay Aware of When You’re Eating
Avoid eating close to bedtime. Restricting food and drink intake in the hours before sleep minimises digestion-related disruptions and prioritises a lower resting heart rate and internal body temperature. Bryan Johnson finishes his last meal 9–10 hours before bed. While that might not be feasible for everyone, experiment with eating your last meal as early as you can to test the impact on your sleep.
5. Limit Evening Blue Light Exposure
Blue light is naturally produced by the sun and artificially produced by screens on your TV, computer, and phone—and it is a maximum-strength sleep disrupter. Blue light signals the brain that it’s daytime, suppressing production of melatonin (the sleep hormone) and promoting wakefulness.
Reduce exposure to artificial blue light from screens and overhead lighting for a couple of hours before bedtime to promote natural melatonin production. Avoiding screens altogether is best. But if you can’t, wear blue light-blocking glasses or use Night Shift (on macOS) or similar functions on your screens to block blue light.
6. Create a Pre-Sleep Routine
Engage in relaxing activities before bed to wind down and signal to the brain that it’s time to sleep. Examples include reading, meditation, or light stretching. Reading in bed has been proven to improve sleep. The key is to perform the same routine consistently. It should start 30–60 minutes before bedtime. But this is your routine, and whatever it is, it should be your personal version of calm and restorative.
7. Manage Bedtime Stress
Reduce stress levels before bed through mindfulness practices, such as meditation, breathwork, or calming rituals. This means avoiding those documentaries about serial killers and action-packed true crime podcasts that get your heart racing and your adrenaline pumping.
8. Keep a Cool Bedroom Temperature
While there is no proven ideal bedroom temperature for everyone, keeping a cool environment helps avoid heat-related disturbances, like when our body temperature rises during REM sleep. Bryan Johnson recommends keeping your bedroom really cold—somewhere between 16–19°C—which aligns with the recommendation of Cleveland Clinic sleep psychologist Michelle Drerup, PsyD.
Other studies suggest setting the thermostat between 19–21°C. Find the right temperature for you, choose breathable bedding, or use cooling devices like a cooling pad or temperature-controlled mattress.
9. Optimise Your Sleep Environment
Creating a cool, dark, quiet sleep environment is a foundational recommendation. Use blackout curtains or a mask to block light. Consider white noise or earplugs to minimise sound. And if you can, invest in a great mattress and pillows. Pillows make a big difference. Make sure that your bedroom is cosy, inviting, and comfortable.
10. Track Your Sleep
What gets measured, gets managed. Tracking sleep patterns using tools like WHOOP, Oura Ring, or other methods is recommended to assess and improve sleep quality over time, and to aid in dialling in your sleep protocols. These tools can show you your sleep needs, duration, wake events, amount of light, deep and REM sleep, respiratory rates, and more.
11. View Morning Sunlight
Get outside within the first 15–30 minutes of waking. Andrew Huberman says, “Morning sunlight increases early-day cortisol release (the ideal time for elevated cortisol) and prepares the body for sleep later that night. Morning sunlight helps regulate your circadian clock—the body’s mechanism for anticipating when to wake up and go to sleep.”
Even 5–10 minutes of sunlight (without sunglasses, a windshield, or window in front of your eyes) upon waking will help. But please, don’t look directly at the sun.
There are some natural supplements that can help promote healthy sleep, when used responsibly. Sleep supplements should be considered a helpful adjunct to the healthy sleep habits listed above, not a replacement for them. Always consult a doctor before taking supplements, as many have side effects and can interact with other medications you may be taking.
Magnesium
Magnesium plays a crucial role in your body’s sleep processes. Think of it as a natural relaxant that helps calm your nervous system and prepare your body for rest. Your body uses magnesium for hundreds of biochemical reactions, but its role in sleep is particularly interesting.
Magnesium aids in regulating neurotransmitters—the chemical messengers that influence your sleep–wake cycles. It also helps maintain healthy levels of GABA (a neurotransmitter that promotes sleep) and helps relax your muscles.
But not all magnesium supplements are created equal. The type you choose matters significantly.
4 Types of Magnesium Supplements:
• Magnesium glycinate is often considered ideal for sleep because it’s well-absorbed and less likely to cause digestive issues.
• Magnesium citrate is another well-absorbed form, though it can have a mild laxative effect.
• Magnesium threonate is newer to the market and may be better at crossing the blood–brain barrier.
• Magnesium oxide is common in supplements but poorly absorbed, making it less effective for sleep support.
Most potential side effects are mild and digestive in nature, like an upset stomach or loose stools. But more serious risks exist for people with kidney problems or those taking certain medications. Muscle weakness, low blood pressure, and in severe cases, heart rhythm changes can be signs of too much magnesium.
If you’re considering magnesium for sleep, start with these guidelines:
• Begin with a lower dose to see how your body responds
• Take it about an hour before bedtime
• Choose a well-absorbed form like magnesium glycinate
• Stay within recommended limits (typically 200–400mg of supplemental magnesium)
Valerian Root
This plant has been used for centuries as a natural remedy for sleep and anxiety. Physicians in ancient Greece and Rome prescribed it for insomnia. The sleep-promoting effects of valerian root appear to work through multiple mechanisms in the brain. It seems to increase GABA production and decrease its breakdown, leading to more GABA availability in the brain.
Research on valerian root presents a mixed but generally promising picture. Some studies show it can help reduce the time needed to fall asleep and improve sleep quality, while others show more modest effects. The most robust evidence suggests that valerian’s benefits might build up over time, working better when taken consistently for a few weeks.
While valerian is generally considered safe for short-term use (typically in doses of 400–900mg), it can cause side effects that include:
• Morning drowsiness
• Vivid dreams
• Headaches
• Digestive upset
• Mild dizziness
More serious risks involve:
• Interaction with sedative medications
• Possible liver effects with long-term use
• Impaired driving if taken too close to morning
• Withdrawal effects if stopped suddenly after long-term use
L-Theanine
L-theanine is a unique amino acid primarily found in green tea leaves that acts as a natural relaxant. When combined with caffeine, as it naturally occurs in tea, L-theanine creates what researchers call “focused relaxation.” The jittery effects of caffeine are reduced while its benefits for attention and alertness are maintained.
L-theanine increases the production of GABA, our primary calming neurotransmitter, while also affecting dopamine and serotonin levels. It’s like a gentle dimmer switch for your brain.
Unlike traditional sleep aids, L-theanine doesn’t force sleep or cause drowsiness. Instead, it helps create conditions conducive to sleep by:
• Reducing racing thoughts and mental chatter
• Lowering anxiety and stress responses
• Promoting alpha brain waves associated with relaxation
• Maintaining a state of “alert relaxation”
Research suggests effective doses range from 100–200mg to promote relaxation and support sleep. Some key points about dosing:
• Effects typically begin within 30–60 minutes
• Can be taken during the day for stress or at night for sleep
• Safe to take on an empty stomach
• Can be combined with other sleep supplements like magnesium
• L-theanine has an excellent safety profile
The recommendations below haven’t been widely researched, but they are popular and worth testing to see if they improve your sleep.
White Noise Machines
These devices produce consistent background noise to mask disruptive sounds.
They can improve sleep by blocking out sudden noises that might wake you, such as traffic or snoring.
Choose a machine with a variety of sound options, like ocean waves or gentle rain, and keep the volume at a comfortable, non-intrusive level.
Weighted Blankets
These heavy blankets are designed to apply gentle, even pressure across the body.
Weighted blankets can reduce anxiety and promote relaxation through deep pressure stimulation, mimicking the calming sensation of a hug.
Choose a blanket that is about 10% of your body weight for the best comfort and effectiveness.
Cooling Pads and Temperature-Controlled Mattresses
These help regulate body temperature during sleep.
A cool sleep environment promotes deeper sleep by aligning with the body’s natural drop in temperature at night.
Keep your sleep space between 16–21°C and consider cooling devices if you struggle with overheating.
Aromatherapy
The use of essential oils like lavender or chamomile can create a more calming atmosphere.
Specific scents can reduce stress and signal to your brain that it’s time to wind down.
Use a diffuser with a few drops of essential oil in your bedroom or spray your pillow with a lavender mist.
Final Thoughts
Our exploration of sleep science has proven how this vital reset shapes our health from cellular to emotional levels. While the biological mechanisms of sleep are universal, how we optimise our sleep is deeply personal.
Improving the quantity and quality of our sleep comes through consistency with the fundamentals. Build on these basics with practices that work for you, remembering that sleep debt compounds over time, while good sleep builds a reservoir of health.
Your needs will evolve, so stay curious, use sleep tracking thoughtfully, and let how you feel be your guide.
Remember: prioritising sleep isn’t self-indulgent. It’s self-preservation, paying dividends across every aspect of your life. Make your bedroom a sanctuary, your bedtime a ritual, and your sleep a priority. A cascade of good things will follow.
Source: Eudēmonia Summit
