BLACK FRIDAY SALE NOW ON - 50% off Site wide

Author: Rob Corso

Longevity is the new frontier, and supplements are its gold rush. Everyone’s chasing more energy, more clarity, more years. A life well-lived is about the combination of good habits, a clear purpose, and healthy connection. That’s the foundation. Within that framework, supplements can definitely help.

They can support and elevate your energy, mood, metabolism, brain function, recovery, and more—when used wisely. But effective supplementation requires patience. Supplements work gradually over time, and many can and should be used in cycles. Before adding anything new, consult a healthcare provider. Ideally, get comprehensive testing to establish your baseline and surface deficiencies or imbalances. This helps ensure you’re targeting your wants and needs, not just chasing trends.

Once you start, track your experience. Journal what you notice: changes in energy, focus, sleep, digestion, mood. Supplements work best when you treat the process as an experiment—with data and awareness, not guesswork. You’ll often hear about “stacks”—strategic combinations of supplements designed to support a specific outcome (like better focus or muscle recovery).

Above all, supplementation is about giving your body the raw materials and support it needs to rebuild, repair, and eventually thrive. It already knows what to do—it just needs the right fuel and conditions.

MITOCHONDRIAL FUNCTION

Mitochondria generate the energy that powers your life—from intense workouts to creative thinking. When these metabolic engines function optimally, you experience better endurance, faster recovery, and more consistent mental and physical energy. The supplements in this category support mitochondrial efficiency and protection, helping you maintain peak performance in daily activities while supporting tissue repair and cellular health for long-term vitality.

It is impossible to overstate the importance of optimal mitochondrial function.

Nicotinamide Adenine Dinucleotide (NAD+) is a vital coenzyme that powers cellular energy production, supports DNA repair, and activates longevity-related enzymes like sirtuins. NAD+ levels drop significantly with age, impacting metabolism, mitochondrial function, and resilience to stress.
The evidence: In animal studies, restoring NAD+ improves metabolism, cognition, and stem cell repair. Human trials show NAD+ precursors like NMN and NR effectively raise NAD+ levels and may support muscle and cardiovascular health.
Why it matters: One of the most promising molecules in ageing science. While long-term effects are still being studied, NAD+ restoration is a well-supported strategy for cellular health and vitality. Supplementation is available via IV drip or transdermal patch, or through precursors like NMN and NR.

Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR) are NAD+ precursors that support cellular energy production, DNA repair, and mitochondrial function. As NAD+ levels decline with age, restoring them may enhance metabolism, endurance, and cognitive performance.
The evidence: Animal studies show improved insulin sensitivity and physical function. Human trials confirm NAD+ levels rise with supplementation, though clinical outcomes are still developing.
Why it matters: Widely used in longevity protocols. Well-tolerated and promising, though long-term human impact is still being studied.

Ubiquinone (CoQ10) is a key player in mitochondrial energy production and cellular defence. It supports ATP synthesis and protects cells from oxidative stress. Levels naturally decline with age.
The evidence: Improves outcomes in older adults when paired with selenium.
Why it matters: A foundational supplement for mitochondrial health—particularly important for those over 40 or taking statins.

Alpha-Lipoic Acid (ALA) and Acetyl-L-Carnitine (ALCAR) work together to support mitochondrial energy metabolism and reduce oxidative damage. ALA is a potent antioxidant, while ALCAR helps transport fatty acids into mitochondria to be used for energy, especially in high-demand tissues like the brain and heart.
The evidence: Shown to reverse markers of ageing in rodents; small human studies support improvements in cognition and energy.
Why it matters: A classic longevity duo with strong mechanistic rationale. May modestly lower blood sugar—something to monitor for diabetics.

Creatine helps regenerate ATP in muscle and brain cells, supporting both physical strength and cognitive performance. It’s especially helpful in preserving lean mass and energy as we age.
The evidence: Backed by robust human studies showing improvements in muscle mass, recovery, and brain function.
Why it matters: One of the safest, most effective, and most studied supplements for healthy ageing.

ANTIOXIDANTS AND IMMUNITY

Your cells face oxidative challenges daily—from exercise and metabolism to environmental exposures. These supplements support your body’s natural defence systems, helping maintain cellular integrity and function across all tissues. With proper antioxidant balance, you may experience better skin quality, improved exercise recovery, enhanced detoxification, and greater resilience to stress. These compounds help you maintain vitality and function now while supporting healthy cellular ageing.

Omega-3 Fatty Acids (EPA/DHA) are essential long-chain fats found in cold-water fish and algae. They play a critical role in brain health, cardiovascular function, and the regulation of inflammation—making them foundational for healthy ageing and wellbeing.
The evidence: Higher omega-3 levels are associated with improved cardiovascular function, slower cognitive decline, and better triglyceride profiles. Blood tests like the Omega-3 Index can help guide dosing. Most people are deficient.
Why it matters: A longevity essential. Aim for 1–2g of combined EPA/DHA daily from high-quality fish or algae oil. A cornerstone of inflammation and brain support.

Glutathione is the body’s master antioxidant, made in the liver, and is essential for detoxification, immune defence, and protection against oxidative damage. It maintains redox balance and helps neutralise cellular stress that accumulates with age.
The evidence: Levels decline with age. Supplementation supports insulin sensitivity, mitochondrial function, and markers of biological ageing.
Why it matters: A central antioxidant for healthy ageing. Best delivered via liposomal or IV forms, or supported through NAC.

METABOLIC HEALTH

Your metabolic function impacts everything from daily energy levels to long-term resilience. These supplements support efficient glucose handling, energy regulation, and cellular adaptability—helping you feel more energetic, mentally sharp, and physically capable today while also building a foundation for future health. Whether you’re looking to enhance athletic performance, maintain healthy weight, or simply feel more vital, optimising metabolic health offers both immediate and lasting benefits.

Berberine is a plant compound long used in traditional Chinese medicine. It supports blood sugar control, enhances insulin sensitivity, and reduces inflammation—similar to metformin.
The evidence: Human studies show strong effects on glucose, cholesterol, and inflammation.

Resveratrol is a polyphenol found in red wine, grapes, and certain berries. It mimics fasting by activating sirtuins and AMPK, and offers antioxidant and anti-inflammatory support.
The evidence: Extends lifespan in yeast, worms, and some mice. Human trials show mixed results, largely due to poor bioavailability.

NEUROPROTECTION AND COGNITIVE SUPPORT

These compounds support focus, memory, stress resilience, and mental clarity—helping you stay sharp, creative, and emotionally balanced. They protect your neurons, neural connections, and brain structures from damage while supporting the neurotransmitter systems that govern mood, memory, and focus.

Lion’s Mane is a medicinal mushroom that stimulates nerve growth factor (NGF), supporting the regeneration of neurons, cognitive performance, and long-term brain health.
The evidence: Improves memory and focus in older adults. Animal studies show it promotes neural repair and growth.
Why it matters: A well-tolerated, safe, natural nootropic with neuroprotective benefits. Best taken consistently to maintain effects.

So, can supplements help? Yes, when approached and executed properly. The right supplements, in the right context, can elevate how you feel, help you reach specific goals, and give your system the boost it needs. But supplements are just that—supplementary. They’re meant to support or enhance systems that are already working well, not replace the fundamentals. Supplements aren’t shortcuts; they’re tools. Use them wisely, and they can help you feel better, think clearer, and recover faster.

It is important to note that supplement quality is largely self-regulated. You’re trusting the manufacturer to do the right thing—and not all of them do. Stick with brands that test for purity and potency.

Even when you’re taking the right stuff, results take time. Building an effective stack can get expensive fast. Some regimens can have you swallowing a small pharmacy every day. So be thoughtful. Know what you’re taking and why. Start small. See how you feel. When you get it right, you can feel the difference.

Disclaimer: This newsletter is provided for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used for diagnosing or treating a health condition, and those seeking personal medical advice should consult a qualified healthcare professional.

Author: Rob Corso

Let’s talk about your second brain.

There is a living, dynamic universe within you. A biological ecosystem so sophisticated that it influences everything from your mood and metabolism to your immune system and mental health. It is a pillar of wellness that scientists are only beginning to understand. That understanding will potentially revolutionise how we think about human health.

Every second of every day, trillions of microscopic bacteria, fungi, and other microorganisms are dancing around in this internal universe. These vast communities of microbes (primarily residing in your large intestine) form what scientists call . . .

THE GUT MICROBIOME.

What was once considered solely digestion is now recognised as a complex and highly synchronised internal world essential to physical health and mental wellness.

The gut’s microbial community is so vast, complex, and influential that it essentially behaves as its own autonomous organ—a second brain, if you will.

This topic can be dense and is often discussed using technical biological terms. While much of the research is generally consistent, some discrepancies exist across various studies. Our aim is to distil and present the information as clearly and accurately as possible.

HOW THE GUT MICROBIOME WORKS

By now, you’ve likely heard the phrase “gut microbiome” quite a bit. Perhaps you know about probiotics and maybe even prebiotics. Even without knowing exactly what it is or how it works, you know the gut microbiome is important.

Here are some wild facts you should know about the gut:

There are more bacterial cells in your body than human cells (40 trillion vs. 30 trillion).

There are at least 1,000 distinct species of bacteria (likely many more) living in the gut. Each performs different tasks in the body. Not all bacteria are bad.

The gut microbiome weighs approximately 2-5 lbs (about the weight of a pineapple).

Around 90% of the body’s serotonin, our body’s “happy” chemical, is produced in the gut.

Your gut contains significantly more neurons than your spinal cord.

About 70-80% of the body’s immune cells are located in your gut’s lymphoid tissue and interact with your microbiome.

Understanding how the gut microbiome affects your health requires exploring three fundamental areas of influence: metabolism, immunity, and the gut-brain connection.

Metabolism

Your gut microbes transform the food you eat into energy and compounds your body can use. They break down fibre into short-chain fatty acids, which nourish your intestinal cells, regulate inflammation, improve insulin sensitivity, and regulate blood sugar levels. Our gut bacteria produce several essential vitamins that our bodies cannot synthesise on their own. The primary vitamins produced include vitamin K and various B vitamins.

Immune System Function

Your gut microbiome is a sophisticated training ground for your immune system. From birth, microbes help immune cells distinguish between what’s friendly and what’s dangerous. Our earliest exposure to microbes—through vaginal delivery, breast milk, and skin-to-skin contact—helps set up our immune system’s baseline.

About 70–80% of the body’s immune cells reside in the gut wall, where they maintain the gut barrier, prevent “leaky gut,” and determine what to attack. Leaky gut occurs when the gut barrier becomes permeable, allowing harmful substances into the bloodstream. This triggers something called endotoxemia, a series of inflammatory responses throughout the body.

The relationship between microbes and immunity is so fundamental that scientists now believe many modern immune disorders, allergies, and chronic inflammation may stem from disrupted microbial communities.

THE GUT–BRAIN CONNECTION

“How is it that the bugs in your gut are connected to your wellbeing? I could go on and on. Everything is connected to the microbiome. How does that make sense given our paradigm? If you are going to your psychiatrist with low mood are they saying, let me look at your poop? Well, they should, okay, literally they should.”

—Dr. Mark Hyman, Eudēmonia Summit 2024

So why do they call it your second brain? For three main reasons:

The gut and brain are connected through neural, hormonal, and immune pathways, with a superhighway called the vagus nerve as a key component in the bidirectional relationship between these organs. 

Second, your gut has its own nervous system, called the enteric nervous system (ENS). It’s often referred to as the “second brain” because it can operate independently of our first brain. It’s an autonomous and self-sustained system, and the ENS has many of the same neurons and neurotransmitters that our first brain has.

Third, and maybe most important, is the neurochemical influence, by which the gut microbiome can profoundly influence our mental and emotional health. Because of the gut–brain axis, emotional and cognitive centres of the brain are directly linked to intestinal functions. This helps explain why digestive health often correlates with mental health.

Research has shown that microbiome disruptions may contribute to anxiety, depression, and even neurodegenerative conditions. Conversely, psychological stress can alter your gut microbiome, creating a feedback loop between mind and microbes. The connection is so strong that scientists have found that transplanting gut bacteria from people with depression into healthy rats can actually make the rats exhibit depressive behaviours. And studies have shown that people with depression or anxiety often have a less diverse microbiome.

In short, a healthy gut could trigger better moods and better brain function.

WHAT INFLUENCES YOUR MICROBIOME

Your gut microbiome is shaped by a complex interplay of factors—from the food you eat to the environment you live in—working together to influence your overall health and well-being.

Diet

Insufficient fibre and excessive consumption of highly refined carbohydrates, processed foods, and refined sugars are among the most common gut disruptors. What you eat has such a profound impact on your gut that your microbes can respond rapidly to dietary changes, often within 24-48 hours. However, establishing a stable and healthy microbiome composition requires consistent, healthy dietary habits.

Lifestyle

Chronic stress and poor sleep have a negative impact on your gut microbiome, as does a sedentary lifestyle that doesn’t prioritise regular exercise.

Medications

Heavy reliance on certain prescription drugs  all contributes to gut dysregulation. Antibiotics can be particularly detrimental, as they significantly alter the gut microbiome by killing both harmful and beneficial bacteria indiscriminately.

Environment

Everything from where you live, the cleaning products you use, and the air you breathe has an impact. The chemicals, pollutants, and pesticides you’re exposed to all influence the stability of your microbiome.

Early Life

Vaginal birth, breast milk, and avoiding early exposure to antibiotics positively shape your initial microbiome.

THE DANGERS OF AN UNHEALTHY GUT

Gut imbalance can manifest in surprising ways, affecting not just digestion but your immune system, mood, skin, energy levels, and more. Here are some key warning signs to watch for.

Digestive Issues: irregular bowel movements, bloating, gas or abdominal discomfort, acid reflux, or heartburn

Immune System Issues: recurring infections, slow wound healing, frequent colds, severe seasonal or food allergies, chronic inflammation

Cognitive Signs: mood changes, brain fog, , irritability

Skin Problems: acne, eczema, rosacea, dry or itchy skin, rashes

Unusual Fatigue: low energy that doesn’t improve with rest, difficulty sleeping

Food Sensitivities: new sensitivities to previously tolerated foods, gluten or dairy intolerance emerging

Hormonal Indicators: irregular menstrual cycles, worsening PMS symptoms, weight fluctuation

It cannot be overstated how important a healthy gut microbiome is to your overall wellness. Disruptions in gut microbiota and gut permeability have been connected to both the causes and effects of a wide range of conditions and diseases, some of which may surprise you.

HOW TO ACHIEVE GUT ENLIGHTENMENT

So what can we do to nurture our gut health and support a balanced microbiome?

01. Eat the Rainbow

Food is mood. This might sound ambitious, but research from the American Gut Project suggests aiming to eat 30 different plant foods weekly. Each colour represents different compounds that feed diverse bacterial communities. Focus on fruits, vegetables, tubers, whole grains, nuts, seeds, and legumes.

This will also get you lots of fibre, which is very important for colon health. A recent study found that higher total dietary fibre intake was associated with a significantly reduced risk of colon cancer. As a rule, aim for 30g of fibre per day.

02. Include Fermented Foods

Fermented foods promote and add healthy bacteria to your gut. These foods include yogurt with live cultures, kombucha, kimchi, sauerkraut, tempeh, pickles in brine, sourdough bread, and miso.

03. Incorporate Probiotics and Prebiotics

Probiotics are “good” bacteria that live in and promote a healthy gut, and are found in the fermented foods listed above. Prebiotics are fibres from plants that serve as food for the probiotics in your gut. We want a diet that includes both, but there are also ways to supplement these.

04. Avoid Sugar and Processed Food 

This is ubiquitous health advice, but it is important to mention that excess sugar and processed foods can promote the growth of harmful bacteria and cause inflammation. In particular, foods high in artificial sweeteners and emulsifiers can alter microbial populations and intestinal barriers.

05. Drink Plenty of Water

Staying hydrated helps maintain the gut’s protective barrier, which aids in preventing conditions like leaky gut.

06. Manage Stress

Stress does all kinds of wacky things to your gut. It impacts digestion, harms the gut’s protective lining (leading to leaky gut), and disrupts the communication of the gut-brain axis, which can lead to mental health issues. Regularly practising meditation, yoga, or anything else that relieves stress in a healthy way is important.

07. Exercise

Aerobic work, strength training, and restorative movement all promote microbial diversity and enhance gut barrier function. Incorporating a balance of brisk walking or jogging or cycling, yoga or pilates, and strength training is a good regimen for a healthy gut—and a generally healthy life.

Incorporating a 10-minute walk after meals has been shown to reduce blood sugar levels up to 35%. Stable blood sugar is important for maintaining a healthy gut microbiome, and it lowers stress and reduces gas and bloating.

08. Spend Time In Nature

Gardening exposes you to a diverse range of microorganisms through your skin, which can support immune function and improve mood. Plus, time outdoors increases vitamin D levels through exposure to sunlight, which also supports gut barrier integrity.

STRATEGIC SUPPLEMENTATION

A diet that prioritises a wide range of plants and incorporates fermented foods should be your primary focus.

You should always consult with a doctor and consider getting tested to understand the health of your gut.

When choosing supplemental probiotics, select products with multiple strains and rotate brands periodically to introduce different beneficial species. Also, certain strains may aid in digestive health, while others might support immune function. Consult a healthcare professional to identify the strain best suited to your health needs, as effects vary from person to person.

You can also consider introducing supplemental prebiotics, but start slowly to avoid digestive discomfort. Some use natural antimicrobial compounds  berberine occasionally to help maintain microbial balance. Finally, Vitamin D may increase microbial diversity, help regulate intestinal barrier integrity, and support immune function in the gut.­

EMERGING TRENDS IN GUT HEALTH

Exciting new treatments and technologies are emerging that could revolutionise how we approach gut health and overall wellness.

Precision Probiotics

This concept is being actively researched, although it’s still in early stages. It uses genetically engineered probiotics for tailored interventions based on individual characteristics and needs.

Microbiome Mapping

Advanced sequencing technologies are used to map individual gut microbiomes. The development of AI-powered platforms for personalised recommendations is an active area of research and commercial development.

Smart Monitoring

Wearable technologies are offering unprecedented insights into digestive system functioning with non-invasive gut health tracking.

GETTING TO THE BOTTOM OF IT ALL

Simply put, our mental health and physical well-being are dependent on a well-functioning, balanced, and diverse microbiome. It’s our second brain, and nurturing this internal ecosystem is one of the most powerful investments we can make into our long-term health.

That health is a direct reflection of our lifestyle, environment, and choices. By supporting this invisible ecosystem, we’re investing in our overall health and well-being in ways that science is only beginning to understand.

As you embark on your journey to optimise your gut health, remember that your microbiome responds best to consistent, nurturing care. Small, daily choices accumulate to create sustainable habits and significant changes. Listen to your body, stay curious about new research, and approach this complex internal world with curiosity and patience.

Disclaimer: This newsletter is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.

Author: Rob Corso

Longevity has a physical signature.

Some parts of it are measurable metrics: numbers you can track over time, like VO₂ max, HRV, and resting heart rate.

Others are functional fitness tests: physical abilities you can lose without realising it, like grip strength, walking speed, and balance.

Both are critical.

Metrics tell you how your internal engine is performing. Tests tell you how the machine moves through the world.

But what exactly should we be measuring and working to improve?

In this issue, we’ll separate the key longevity indicators into two categories:

• Physiological Metrics: Measurable biological values like VO₂ max and HRV

• Physical Performance Benchmarks: Functional tests like push-ups and dead-hangs

The internal, physiological metrics offer a powerful snapshot of your body’s current and future health. But those numbers aren’t the whole story. To predict how well you’ll function as you age—your physical performance might matter just as much.

Let’s dig in.

KEY PHYSIOLOGICAL METRICS

These core biological measurements are some of the strongest predictors of how long—and how well—you’ll live. They’re the vital signs of longevity, and you can track and improve every one of them.

VO₂ Max

(Cardiorespiratory Fitness)

VO₂ max measures the maximum amount of oxygen your body can utilise during intense exercise. It’s a marker of aerobic capacity and cardiovascular fitness.

VO₂ max is arguably the strongest predictor of longevity.

How to Test It: The gold standard is a laboratory cardiopulmonary exercise test (CPET), where you wear a mask that measures oxygen consumption while exercising to exhaustion. Fitness watches estimate VO₂ max using heart rate data and exercise intensity. The Rockport Walking Test offers a low-tech alternative: walk 1.6 kilometers (1600 meters) as fast as possible, record your time and heart rate at completion, then calculate your VO2 max using standardised formulas available online.  Alternatively, try the The Cooper Test—running as far as possible in 12 minutes—is another widely used field test with reliable estimation formulas.

  Use a standardised formula to estimate your VO₂ max based on total distance. Aiming for 2,500 metres or more puts most middle-aged adults in the 75th percentile or above, with elite athletes often exceeding 3,200 metres. Even modest improvements from baseline can significantly reduce mortality risk.

How to Improve: Zone 2 cardio training (working at about 70-80% of maximum heart rate) is the most efficient approach, ideally for 3–5 hours weekly. Add 1–2 weekly HIIT sessions for even greater gains. Many people see a 10–15% boost in a year.

Muscle Mass

maintaining found that higher muscle mass is associated with a 20% lower risk of all-cause mortality, independent of fat mass or BMI, highlighting the importance of maintaining lean tissue.

How to Test It: The gold standard for measuring muscle mass is a DEXA (Dual-Energy X-ray Absorptiometry) scan, which provides detailed body composition data, including lean muscle mass, fat mass, and bone density. Bioelectrical impedance analysis (BIA) scales, which send a small electrical current through the body to estimate muscle mass, are a convenient alternative. These smart scales can track changes over time.

Where You Should Be: While specific muscle mass targets vary by height and frame size, being in the top 50% of your age group is a strong start. Top 25% is ideal. After 30, people typically lose 3–5% of muscle per decade without intervention.

How to Improve: Lift weights 2-3 times weekly, focusing on compound movements that engage multiple muscle groups. Proper protein intake supports this training, too. And as we keep seeing, adequate sleep helps, as it supports recovery.

HEART RATE VARIABILITY (HRV)

HRV reflects the variation in time between heartbeats and indicates how well your nervous system handles stress and recovery and is an excellent daily indicator of overall physiological balance.

Where You Should Be: There is no universal benchmark for HRV, as it varies significantly between individuals based on age, fitness level, and genetics. The key is to establish a personal baseline and track trends over time. Higher HRV generally means better fitness and resilience.

How to Test It: The most accessible way to measure HRV is through wearable devices that track fitness data.

How to Improve: Regular Zone 2 training, as well as strength training, has been shown to boost HRV. Meditation, breathwork, adequate sleep, sauna and cold plunge, and cutting back on alcohol all positively impact HRV.

RESTING HEART RATE (RHR)

Resting heart rate is exactly what it sounds like: the number of times your heart beats per minute when you’re completely at rest. It’s best measured first thing in the morning before getting out of bed. A lower RHR usually means a stronger, more efficient heart.

Where You Should Be: A resting heart rate below 70 bpm is good, with below 60 bpm considered excellent for the general population. Elite endurance athletes often have resting heart rates in the 40s, though this level isn’t necessary for longevity benefits. The key is maintaining a lower RHR as you age, rather than allowing it to drift upward. 

How to Test It: Count your pulse for 60 seconds upon waking or use a wearable that tracks it overnight. For the most reliable results, take measurements at the same time each day, ideally after a full night’s sleep and before any caffeine consumption.

How to Improve: The most effective way to lower RHR is consistent aerobic exercise, particularly Zone 2 cardio. Three to four 30-minute sessions weekly can reduce RHR by 5–10 bpm within six months. Improving sleep quality, managing stress through meditation or breathwork, and maintaining proper hydration will help. Limiting stimulants like caffeine and reducing alcohol consumption also help optimise RHR.

PHYSICAL PERFORMANCE BENCHMARKS

These real-world tests don’t just measure fitness—they predict how well you’ll move, age, and maintain independence over time. They reveal what’s happening beneath the surface, long before symptoms show up.

GRIP STRENGTH

Where You Should Be: For men, above 40kg is excellent; for women, above 25kg. While age-adjusted norms exist, stronger is better—aim for the top 25% in your age group. More important than absolute numbers is preventing the decline that typically occurs with age.

How to Improve: While specific grip strengthening tools can help, compound movements that challenge grip indirectly often yield better results. Deadlifts without straps, farmer’s carries, pull-ups, and dead hangs are particularly effective. For a simple daily practice, hanging from a pull-up bar for an accumulated time of 2–3 minutes daily has shown remarkable benefits for both grip strength and shoulder health.

GAIT SPEED (WALKING SPEED)

2011 JAMA study found that people who walk faster than 1.2 meters per second (2.7 mph) live significantly longer than slower walkers.

Where You Should Be: 1.2 m/s is the benchmark—that’s 400 meters (a quarter mile) in under 6 minutes at a natural pace. Speeds above 1.4 m/s are linked to even better longevity outcomes.

How to Improve: Leg strength training (particularly squats, lunges, and hip hinges) provides the foundation. Regular walking practice at a slightly faster pace helps. Many find that rucking—walking with a weighted backpack—is effective for faster natural walking speeds. Balance exercises also contribute to more confident, faster walking.

PUSH-UP CAPACITY

Where You Should Be: 

Men:

• 40+ push-ups: Excellent

• 20–40 push-ups: Good

• 10–20 push-ups: Moderate risk

• <10 push-ups: Higher risk

Women:

• 30+ push-ups: Excellent

• 15–30 push-ups: Good

• 5–15 push-ups: Moderate risk

• <5 push-ups: Higher risk

How to Improve: If you can’t yet do standard push-ups, build up gradually: start with wall push-ups, then move to incline push-ups before progressing to the floor. If you’re already doing standard push-ups, try the “grease the groove” method—multiple sets throughout the day, stopping well before failure. To advance further, add weight or use handles to increase range of motion with deficit push-ups.

DEAD HANG

A dead hang is the ability to hang from a pull-up bar with arms fully extended for a prolonged period. It tests grip strength, shoulder stability, and upper back engagement. Dr. Peter Attia includes the 2-minute dead hang in his “Centenarian Decathlon”—his framework for training the body to thrive into one’s 90s and beyond. That’s helped establish the dead hang as a practical benchmark in the modern longevity toolkit.

Where You Should Be: A 2-minute dead hang signals excellent shoulder and grip health. Beginners can aim for 30 seconds as a starting point.

How to Improve: Do 3–4 max-effort hangs per session, 3x/week, resting fully between sets. If hanging is too difficult at first, use a bench to offload weight. Active hangs (shoulders engaged, not passive) build strength faster. Once you can hang for 90 seconds, add weight with a vest or dip belt to keep progressing.

WALL SIT

Another of Dr. Attia’s assessments, this isometric hold tests lower body endurance and core stability—factors closely linked to functional independence with aging.

Where You Should Be: Dr. Attia recommends being able to hold a proper wall sit (back against wall, thighs parallel to floor, knees at 90 degrees) for 2 minutes. It’s difficult, so 45–60 seconds is a common starting point.

How to Improve: Practice 3 sets of your max hold, 3x per week. Add 5–10 seconds each week. Once you hit 90+ seconds, hold lightweight at your chest for added difficulty. Squats and lunges also build the strength needed for longer wall sits.

FARMER’S CARRY

The farmer’s carry is a simple but powerful test of your ability to walk while holding heavy weights in each hand. This test combines grip, core, and full-body endurance—essential for everyday strength.

Where You Should Be: Carry your body weight (split between both hands) for 2 minutes. A solid starting point: 50% of your body weight for 1 minute.

How to Improve: Start by finding the heaviest weight you can carry for 1 minute. Train with 70–80% of that load, gradually increasing time or weight. Do 2–3 sessions per week. Pair with deadlifts or pull-ups for faster gains.

SIT-TO-STAND TEST (SITTING-RISING TEST, SRT)

This test assesses your ability to move from standing to sitting on the floor and back up with minimal support—a real-world measure of strength, balance, and coordination.

Where You Should Be: The standardised version of this test uses a 10-point scale, deducting one point each time a hand, arm, or knee is used for support.

How to Improve: Practice the movement daily. Support it with deep squats, hip and ankle mobility work, core training, and balance drills. Even simple habits like regularly sitting on the floor can help train the mobility required.

ONE-LEG BALANCE

Where You Should Be: Hold for at least 10 seconds with eyes open and hands on hips. Better still: 30+ seconds with eyes open, or 10+ seconds with eyes closed. You’ll be surprised at how challenging this can be.

How to Improve: Practice daily—stand on one leg while brushing your teeth or waiting for coffee. Add single-leg deadlifts, pistol squats, or unstable surface work. Tai Chi and yoga are excellent long-term balance builders.

LEG STRENGTH

Lower body strength is perhaps the most critical physical attribute for maintaining independence with age. A 2014 American Journal of Medicine study identified leg weakness as a primary risk factor for frailty and loss of mobility.

Where You Should Be: While there’s no single standardised test, good benchmarks include:

• Ability to perform 20+ proper bodyweight squats with good form

• Ability to ascend stairs without using handrails

• Ability to rise from a chair without using arms for assistance

• For those who strength train, deadlifting 75–100% of bodyweight for multiple repetitions

How to Improve: Base your training on squats, lunges, step-ups, and deadlifts. Beginners can start with bodyweight work; progress gradually using weights and resistance. Train legs 2–3 times weekly with proper recovery.

THE INTERCONNECTED NATURE OF HEALTH METRICS

These metrics and benchmarks don’t exist in isolation. Improve one, and you often improve many.

These are the fundamentals that build your physiological signature for aging well.

Zone 2 cardio raises VO₂ max, lowers resting heart rate, and brings your nervous system into balance. Even a little daily mobility work makes you better at walking, balancing, and getting off the floor.

If you’re just starting out, the formula doesn’t need to be complicated:

• Lift weights 2–3 times a week—focus on big, compound movements.

• Do 3+ hours of Zone 2 cardio, broken up however you need.

• Stretch, move, or mobilise daily—even 5 minutes counts.

• Get serious about sleep. It underpins everything else.

Master the basics. They give you something numbers rarely offer: clarity.

You’ll know what’s working. You’ll know where to focus.

And the payoff ismore energy, less pain, better moods, and the quiet confidence of a body that can still do what you ask of it.

We’re living longer than ever. If you start now, you can build a body that can carry you farther than you’d imagine.

Disclaimer: This newsletter is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.

Source: Eudēmonia Summit

Author: Rob Corso

Your immune system is more than a cold-fighting machine.

It’s your body’s surveillance network, inflammation modulator, and recovery crew all rolled into one. Your immune system shapes how you age, how quickly you recover, how you sleep, your internal and external inflammation, and even how well your brain works.

It’s one of those things that you forget about when it’s working well. But when it doesn’t, there’s nothing else you think about.

The good news is you can train it. Modulate it. Improve it. Of course, it boils down to what most things boil down to: good habits.

Just about every issue we’ve published touches on immunity.

Let’s explore the full spectrum of immune health: what strengthens it, what sabotages it, and how to make yours more intelligent over time.

Immunity 101: How It Works

Your immune system is exactly that—a system. It’s a distributed network made up of cells, tissues, and signals that span nearly every part of your body, from bone marrow and the gut to your skin and lymph nodes.

There are two main arms:

• Innate immunity is your first responder. It acts fast and broadly. It doesn’t care what the invader is; it just wants it gone. Think of inflammation, fever, and the mobilisation of white blood cells for cuts and bruises.

• Adaptive immunity is your specialist team. It learns from past encounters and remembers pathogens for years or even decades. It creates antibodies and immune memory (via T-cells and B-cells) to respond more efficiently to future threats. This is why, for instance, you typically get chickenpox only once. Your adaptive immune system filed that threat away in its permanent memory bank.

These two arms work together. Ideally, innate immunity holds the line while adaptive immunity gears up a specific defence.

But here’s the nuance: A healthy immune system isn’t one that’s always “strong.” It’s one that’s well-regulated. It knows when to act and when to stand down. 

With age, immune responses get slower and less precise This decline is called immunosenescence

Much of what we call “aging” is really this slow drift into immune dysfunction. Understanding how the system works is the first step to supporting it intelligently.

The Foundations of Immune Health

The real foundation of immune resilience isn’t found in pills and powders; it’s built from your daily habits. Sleep, food, movement, stress, relationships, and gut health are what create the conditions for a responsive, regulated immune system.

You don’t need to be perfect. But consistency compounds, and that’s the basis of a strong anything.

Sleep

Sleep is when your immune system does its most important work. During deep sleep, your body produces cytokines that fight infection and inflammation, while your brain’s glymphatic system clears metabolic waste.

Your immune system runs on a circadian rhythm, with key immune cells rising and falling in sync with your sleep-wake cycle. Sleep is so critical to immune function that those who sleep less than 6 hours nightly are 4x more likely to catch a cold.

Growth hormone, released during deep sleep, stimulates immune cell production. Memory T-cells and B-cells consolidate their “training” during sleep. Sleep also reduces natural killer cell activity by 72% with just one night of 4-hour sleep.

→ The Sleep Issue breaks down exactly how to get deeper sleep and stronger immunity.

Nutrition

You are what you eat. And your immune system is metabolically expensive, meaning it requires specific nutrients to function optimally.

Micronutrients like vitamins CDzinc, and selenium are essential to immune cell function. Fibre feeds gut bacteria, which in turn regulate immune balance. Too many ultra-processed foods can trigger low-grade inflammation.

Eat whole foods. Emphasise plants, legumes, nuts, and fermented items. Eat foods full of polyphenols, vitamins and flavonoids. Think nourishment, not restriction.

Exercise

Exercise is one of the most powerful immune modulators available. Regular movement increases circulation, helping immune cells patrol your body more effectively, while also reducing chronic inflammation.

Exercise enhances immunity by increasing production of antibodies and white blood cells; raising body temperature during and after, which may help fight infections; reducing stress hormones that suppress immune function; and improving sleep quality.

→ Guess what? We did an entire issue on fitness for longevity.

Stress

Acute stress can be helpful. Chronic stress, not so much. When stress hormones like cortisol remain elevated, they suppress immune function and increase inflammation.

Chronic stress also shortens telomeres, accelerating cellular aging. Daily stress hygiene matters: breathwork, meditation, nature walks, creative time. Even a few deep breaths can shift your state.

Gut Health

Roughly 70% of your immune system lives in your gut. The microbiome helps regulate inflammation, train immune cells, and maintain tolerance.

Feed it with fibre, polyphenols, and fermented foods. 

Social Connection

Humans are inherently social creatures, and meaningful relationships actually boost immune resilience. Socially connected people have stronger antibody responses to vaccines, and social support is shown to reduce stress hormones.

Strategies for Immune Optimisation

Intermittent Fasting

Emerging research suggests that periodic fasting may help “reset” the immune system by promoting autophagy—the cellular cleanup process that removes damaged components.

Fasting can reduce chronic inflammation, promote regeneration of immune cells, clear senescent (aged) cells, and improve metabolic health, which supports immune function.

But be careful, extreme or prolonged fasting may be detrimental to immune function.

Temperature Therapy

Both heat and cold exposure create beneficial stress that strengthens your immune system through hormesis—the process where mild stressors make you more resilient.

Sauna use has some of the most compelling research for immune enhancement and longevity. Regular sauna sessions create beneficial heat stress that strengthens your immune system

Micronutrient Optimisation

While a healthy diet should provide most nutrients, certain supplements may support immune function, especially as we age:

• Vitamin D3 boosts your immune system by activating pathogen-fighting cells and reducing harmful inflammation. Without it, your defences stay sluggish and overreactive.

• Omega-3 fatty acids support anti-inflammatory processes and immune cell membrane function

• Probiotics may help maintain gut barrier function and immune balance.

• Prebiotics strengthen immunity by feeding gut bacteria that produce short-chain fatty acids, which calm inflammation and help regulate immune responses. A healthier gut means a smarter, more balanced immune system.

• Magnesium supports over 300 enzymatic reactions, including those involved in immune function.

Always consult healthcare providers before starting supplements, especially if you have health conditions or take medications.

Meditation

Meditation isn’t just about stress relief—it’s one of the most scientifically validated ways to directly enhance immune function. Recent research shows that mindfulness meditation produces measurable changes in immune system activity, including reduced inflammation markers and increased immune cell function.

A groundbreaking University of Florida study found that just eight days of intensive meditation caused robust activation of the immune system

Nasal Breathing

One of the simplest yet most overlooked immune practices is how you breathe. Your nose isn’t just for smelling—it’s a sophisticated filtration and immune enhancement system.

Nasal breathing activates multiple immune benefits  including natural air filtration through nasal hairs and mucous membranes that trap pathogens, nitric oxide production with powerful antimicrobial properties, and air conditioning that warms and humidifies incoming air.

Practice conscious nasal breathing during daily activities, consider mouth taping at night if you’re a chronic mouth breather (consult a healthcare provider for sleep apnoea concerns), and try alternate nostril breathing exercises for 5–10 minutes daily.

Red Flags to Monitor

Watch for these warning signs that your immune system may be compromised:

• Getting sick more than 3 times per year

• Infections that are unusually severe or long-lasting

• Slow wound healing

• Persistent fatigue despite adequate sleep

• Frequent digestive issues

• Skin problems like eczema or frequent breakouts

• Allergies that are worsening or new food sensitivities

The Bottom Line

Your immune system is writing your health future with every choice you make today.

Unlike some aspects of aging, immune resilience isn’t fixed or fated. It’s adaptive. Forgiving. And remarkably responsive—even decades into life.

The immune system rewards consistency. Not perfection.

It remembers what you teach it. T-cells trained now will still be smarter years from now. Gut diversity you build this season becomes a living archive of defences for later.

Even better? It’s never too late to begin. 

The goal isn’t to avoid every illness. The goal is to build a body that knows how to recover.

That’s what a strong immune legacy looks like: not fragile and reactive, but calm, capable, and prepared.

Disclaimer: This newsletter is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician.

Source: Eudēmonia Summit

Author: Rob Corso

There’s one thing you (hopefully) do every day that’s the most transformative tool in health and wellness. It isn’t a supplement, workout or meditation. It’s the most potent biological upgrade available to you every single day—your most dynamic recovery tool designed to recharge your brain, rebuild your body, and optimise your health from the inside out.

SLEEP.

Sleep is fascinating. Did you know it does all of this?

• Removes dangerous toxins from your brain

• Reboots and charges your immune system

• Cleans and repairs your cells

• Balances your hormones

• Organises your memories

• Improves cognition and performance

Poor sleep is linked to a myriad of physical and mental health problems, from chronic illness and heart disease to anxiety and depression. Sleep and mental health have a bidirectional relationship: poor sleep can worsen mental health conditions, while anxiety and depression often disrupt sleep patterns.

The difference between the amount of sleep you need and what you get (called “sleep debt”) accumulates like credit card debt. You’ll eventually have to pay—and with interest. Even missing 1–2 hours per night creates a deficit so significant that it can take weeks to fully reverse the negative impacts. That’s why it’s crucial to take sleep seriously: of all the longevity practices and wellness strategies, high-quality sleep is the most impactful way to protect your health and wellbeing.

Yet for many, it remains elusive and irregular. Below we’ll explore:

• How sleep works

• Why it’s so important

• What the experts have to say

• Strategies to optimise your sleep

Before we dig into the strange magic about sleep, it’s important to note that there’s still a lot we don’t know. The relationship between sleep, consciousness and brain function remains a fascinating area of ongoing research. However, decades of scientific study have given us valuable insights into how sleep works and its crucial role in our health.

HOW SLEEP WORKS

When you fall asleep, your body enters into a highly organised sleep routine cycling between Non-Rapid Eye Movement (NREM) Sleep—which accounts for 75–80% of sleep—and Rapid Eye Movement (REM) Sleep.

NREM sleep has three stages.

N1: Light Sleep
Your body starts to relax and brain activity slows, entering the gateway to deeper sleep.

N2: Intermediate Sleep
Your heart rate slows and your brain activity changes, producing sleep spindles. These short bursts of rapid brain activity play a key role in long-term memory consolidation and blocking out external distractions.

N3: Deep Sleep
In the most restorative phase of sleep, muscles are repaired, growth hormones are released, and your immune system gets a serious boost. N3 is vital for clearing out waste, like a power wash for the brain.

The glymphatic system flushes out toxins and metabolic byproducts that build up during the day—compounds strongly associated with cognitive issues and neurodegenerative diseases like Alzheimer’s or dementia. Without sufficient deep sleep, this cleaning process is impaired, leading to a gradual accumulation of harmful substances over time.

REM sleep is where things get really interesting.
REM is the most mysterious phase of sleep and the interval when your brain is most active. This is when you dream, organise and file memories, process emotions, and strengthen creative connections.

During this phase, your eyes dart back and forth beneath your closed eyelids, while your body remains mostly paralysed to prevent you from acting out your dreams.

Memory Consolidation and Learning
REM is critical for procedural and long-term memory (learning how to perform tasks) and emotional memory (sorting through the day’s experiences, deciding what to keep and what to discard). New neural connections are formed and strengthened during REM, making it essential for problem-solving, creativity, and neuroplasticity.

Emotional Processing
REM sleep helps process and “digest” emotions—especially negative ones like fear and anxiety—by reactivating emotional memories in a safe, dreamlike environment. This enables the brain to neutralise their intensity, making emotional challenges easier to handle.

Creativity and Problem-Solving
The chaotic, nonlinear nature of REM dreams fosters out-of-the-box thinking, helping the brain make novel connections. That’s why people often wake up with new ideas or solutions to problems they struggled with the day before.

REM sleep is yoga for the brain, ensuring it remains adaptable, flexible and pliable. Without a sufficient amount, you’ll have lower emotional resilience, impaired learning, weakened creativity and overall cognitive decline.

These cycles repeat every 90 minutes, getting shorter as the night progresses. Deep sleep dominates early on, while REM sleep lengthens toward the morning. This aligns with the body’s circadian rhythm, emphasising physical restoration earlier in the night, and cognitive and memory consolidation later on.

So how much do you need? One to two hours of REM sleep and 1–3 hours of deep sleep per night is optimal.

How To Get The Sleep You’ve Always Dreamed Of

The pattern and quality of sleep (our “sleep architecture”) changes significantly throughout our lives.

• Newborns spend up to 17 hours sleeping in short bursts, with about 50% of their sleep time in REM, which is crucial for their rapidly developing brains.

• Children and teenagers need more sleep than adults (8–10 hours) and naturally tend toward later bedtimes due to shifts in their circadian rhythm during puberty.

• Adults settle into more stable patterns, but women’s sleep needs often fluctuate with hormonal changes during menstruation, pregnancy and menopause.

The scientific consensus is that, regardless of gender, most adults need 7–9 hours of sleep per night. As we age, sleep becomes lighter and more fragmented, with less time spent in deep sleep stages. This is why older adults might sleep the same number of hours but feel less rested, making sleep hygiene practices increasingly important.

There is evidence that some individuals may need less sleep. Some people have a genetic mutation (DEC2) that allows them to function normally on just 4–6 hours of sleep. However, these cases are rare.

Regardless of your age and gender, it’s clear that the quality and efficiency of your sleep is paramount. That’s why we’re here to help you optimise sleep to the best of your ability.

The 11 Sleep Optimisation Strategies You Need

So what do the experts say?
At the first Eudēmonia Summit, we were joined by some of today’s foremost sleep experts: Dr Michael Breus (The Sleep Doctor); longevity pioneer and sleep athlete Bryan Johnson; sleep coach Jack Dell’Accio; and popular neuroscientist and podcaster Andrew Huberman.

Like anything worth doing, high-quality sleep requires a commitment to good habits. Below are some principles and strategies—researched and recommended by our experts—that are essential for improving sleep.

1. Maintain a Consistent Sleep Schedule
All sleep experts emphasise the importance of maintaining regular bedtimes and wake times, even on weekends, to align with the body’s circadian rhythm. Pick a bedtime and stick to it. Bryan Johnson says, “Your bedtime is your most important appointment today, and every day.”

2. Exercise Earlier in the Day
Exercise and sleep create an effective flywheel, as one boosts the other. Regular exercise primes your body for restful sleep, and quality sleep prepares your body for physical strain. A balance of strength training (which enhances deep sleep) and aerobic activity (which improves sleep latency and duration) is ideal. But no matter what you do, experts agree that you should finish workouts at least a few hours before bed to prevent overstimulation. Early workouts align more with our circadian rhythm.

3. Avoid Caffeine and Alcohol
Avoid caffeine and any other stimulant for at least 6–8 hours (more if you can) before bed. Though some people metabolise caffeine faster than others, see if it has an impact on your sleep by experimenting with your timing. Limit or eliminate alcohol in the evening, as it disrupts the sleep cycle. Though alcohol may help you fall asleep, it damages your sleep quality.

4. Stay Aware of When You’re Eating
Avoid eating close to bedtime. Restricting food and drink intake in the hours before sleep minimises digestion-related disruptions and prioritises a lower resting heart rate and internal body temperature. Bryan Johnson finishes his last meal 9–10 hours before bed. While that might not be feasible for everyone, experiment with eating your last meal as early as you can to test the impact on your sleep.

5. Limit Evening Blue Light Exposure
Blue light is naturally produced by the sun and artificially produced by screens on your TV, computer, and phone—and it is a maximum-strength sleep disrupter. Blue light signals the brain that it’s daytime, suppressing production of melatonin (the sleep hormone) and promoting wakefulness.
Reduce exposure to artificial blue light from screens and overhead lighting for a couple of hours before bedtime to promote natural melatonin production. Avoiding screens altogether is best. But if you can’t, wear blue light-blocking glasses or use Night Shift (on macOS) or similar functions on your screens to block blue light.

6. Create a Pre-Sleep Routine
Engage in relaxing activities before bed to wind down and signal to the brain that it’s time to sleep. Examples include reading, meditation, or light stretching. Reading in bed has been proven to improve sleep. The key is to perform the same routine consistently. It should start 30–60 minutes before bedtime. But this is your routine, and whatever it is, it should be your personal version of calm and restorative.

7. Manage Bedtime Stress
Reduce stress levels before bed through mindfulness practices, such as meditation, breathwork, or calming rituals. This means avoiding those documentaries about serial killers and action-packed true crime podcasts that get your heart racing and your adrenaline pumping.

8. Keep a Cool Bedroom Temperature
While there is no proven ideal bedroom temperature for everyone, keeping a cool environment helps avoid heat-related disturbances, like when our body temperature rises during REM sleep. Bryan Johnson recommends keeping your bedroom really cold—somewhere between 16–19°C—which aligns with the recommendation of Cleveland Clinic sleep psychologist Michelle Drerup, PsyD.
Other studies suggest setting the thermostat between 19–21°C. Find the right temperature for you, choose breathable bedding, or use cooling devices like a cooling pad or temperature-controlled mattress.

9. Optimise Your Sleep Environment
Creating a cool, dark, quiet sleep environment is a foundational recommendation. Use blackout curtains or a mask to block light. Consider white noise or earplugs to minimise sound. And if you can, invest in a great mattress and pillows. Pillows make a big difference. Make sure that your bedroom is cosy, inviting, and comfortable.

10. Track Your Sleep
What gets measured, gets managed. Tracking sleep patterns using tools like WHOOP, Oura Ring, or other methods is recommended to assess and improve sleep quality over time, and to aid in dialling in your sleep protocols. These tools can show you your sleep needs, duration, wake events, amount of light, deep and REM sleep, respiratory rates, and more.

11. View Morning Sunlight
Get outside within the first 15–30 minutes of waking. Andrew Huberman says, “Morning sunlight increases early-day cortisol release (the ideal time for elevated cortisol) and prepares the body for sleep later that night. Morning sunlight helps regulate your circadian clock—the body’s mechanism for anticipating when to wake up and go to sleep.”
Even 5–10 minutes of sunlight (without sunglasses, a windshield, or window in front of your eyes) upon waking will help. But please, don’t look directly at the sun.

Natural Sleep Supplements

There are some natural supplements that can help promote healthy sleep, when used responsibly. Sleep supplements should be considered a helpful adjunct to the healthy sleep habits listed above, not a replacement for them. Always consult a doctor before taking supplements, as many have side effects and can interact with other medications you may be taking.

Magnesium
Magnesium plays a crucial role in your body’s sleep processes. Think of it as a natural relaxant that helps calm your nervous system and prepare your body for rest. Your body uses magnesium for hundreds of biochemical reactions, but its role in sleep is particularly interesting.

Magnesium aids in regulating neurotransmitters—the chemical messengers that influence your sleep–wake cycles. It also helps maintain healthy levels of GABA (a neurotransmitter that promotes sleep) and helps relax your muscles.

But not all magnesium supplements are created equal. The type you choose matters significantly.

4 Types of Magnesium Supplements:

• Magnesium glycinate is often considered ideal for sleep because it’s well-absorbed and less likely to cause digestive issues.

• Magnesium citrate is another well-absorbed form, though it can have a mild laxative effect.

• Magnesium threonate is newer to the market and may be better at crossing the blood–brain barrier.

• Magnesium oxide is common in supplements but poorly absorbed, making it less effective for sleep support.

Most potential side effects are mild and digestive in nature, like an upset stomach or loose stools. But more serious risks exist for people with kidney problems or those taking certain medications. Muscle weakness, low blood pressure, and in severe cases, heart rhythm changes can be signs of too much magnesium.

If you’re considering magnesium for sleep, start with these guidelines:

• Begin with a lower dose to see how your body responds

• Take it about an hour before bedtime

• Choose a well-absorbed form like magnesium glycinate

• Stay within recommended limits (typically 200–400mg of supplemental magnesium)

Valerian Root
This plant has been used for centuries as a natural remedy for sleep and anxiety. Physicians in ancient Greece and Rome prescribed it for insomnia. The sleep-promoting effects of valerian root appear to work through multiple mechanisms in the brain. It seems to increase GABA production and decrease its breakdown, leading to more GABA availability in the brain.

Research on valerian root presents a mixed but generally promising picture. Some studies show it can help reduce the time needed to fall asleep and improve sleep quality, while others show more modest effects. The most robust evidence suggests that valerian’s benefits might build up over time, working better when taken consistently for a few weeks.

While valerian is generally considered safe for short-term use (typically in doses of 400–900mg), it can cause side effects that include:

• Morning drowsiness

• Vivid dreams

• Headaches

• Digestive upset

• Mild dizziness

More serious risks involve:

• Interaction with sedative medications

• Possible liver effects with long-term use

• Impaired driving if taken too close to morning

• Withdrawal effects if stopped suddenly after long-term use

L-Theanine
L-theanine is a unique amino acid primarily found in green tea leaves that acts as a natural relaxant. When combined with caffeine, as it naturally occurs in tea, L-theanine creates what researchers call “focused relaxation.” The jittery effects of caffeine are reduced while its benefits for attention and alertness are maintained.

L-theanine increases the production of GABA, our primary calming neurotransmitter, while also affecting dopamine and serotonin levels. It’s like a gentle dimmer switch for your brain.

Unlike traditional sleep aids, L-theanine doesn’t force sleep or cause drowsiness. Instead, it helps create conditions conducive to sleep by:

• Reducing racing thoughts and mental chatter

• Lowering anxiety and stress responses

• Promoting alpha brain waves associated with relaxation

• Maintaining a state of “alert relaxation”

Research suggests effective doses range from 100–200mg to promote relaxation and support sleep. Some key points about dosing:

• Effects typically begin within 30–60 minutes

• Can be taken during the day for stress or at night for sleep

• Safe to take on an empty stomach

• Can be combined with other sleep supplements like magnesium

• L-theanine has an excellent safety profile

Sleep Tools

The recommendations below haven’t been widely researched, but they are popular and worth testing to see if they improve your sleep.

White Noise Machines
These devices produce consistent background noise to mask disruptive sounds.
They can improve sleep by blocking out sudden noises that might wake you, such as traffic or snoring.
Choose a machine with a variety of sound options, like ocean waves or gentle rain, and keep the volume at a comfortable, non-intrusive level.

Weighted Blankets
These heavy blankets are designed to apply gentle, even pressure across the body.
Weighted blankets can reduce anxiety and promote relaxation through deep pressure stimulation, mimicking the calming sensation of a hug.
Choose a blanket that is about 10% of your body weight for the best comfort and effectiveness.

Cooling Pads and Temperature-Controlled Mattresses
These help regulate body temperature during sleep.
A cool sleep environment promotes deeper sleep by aligning with the body’s natural drop in temperature at night.
Keep your sleep space between 16–21°C and consider cooling devices if you struggle with overheating.

Aromatherapy
The use of essential oils like lavender or chamomile can create a more calming atmosphere.
Specific scents can reduce stress and signal to your brain that it’s time to wind down.
Use a diffuser with a few drops of essential oil in your bedroom or spray your pillow with a lavender mist.

Final Thoughts
Our exploration of sleep science has proven how this vital reset shapes our health from cellular to emotional levels. While the biological mechanisms of sleep are universal, how we optimise our sleep is deeply personal.

Improving the quantity and quality of our sleep comes through consistency with the fundamentals. Build on these basics with practices that work for you, remembering that sleep debt compounds over time, while good sleep builds a reservoir of health.

Your needs will evolve, so stay curious, use sleep tracking thoughtfully, and let how you feel be your guide.

Remember: prioritising sleep isn’t self-indulgent. It’s self-preservation, paying dividends across every aspect of your life. Make your bedroom a sanctuary, your bedtime a ritual, and your sleep a priority. A cascade of good things will follow.

Source: Eudēmonia Summit